Mammalian neuronal actions of FMRFamide and the structurally related opioid Met-enkephalin- Arg6-Phe7
| Autor: | R. J. Gayton |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Male
Met-enkephalin endocrine system medicine.medical_specialty Enkephalin Enkephalin Methionine Action Potentials (+)-Naloxone chemistry.chemical_compound Neurons Efferent Internal medicine medicine Animals FMRFamide Opioid peptide Receptor Medulla Medulla Oblongata Multidisciplinary Naloxone Rats Inbred Strains Enkephalins Rats Endocrinology nervous system chemistry Opioid Receptors Opioid Endorphins Oligopeptides Enkephalin Leucine medicine.drug |
| Zdroj: | Nature. 298:275-276 |
| ISSN: | 1476-4687 0028-0836 |
| DOI: | 10.1038/298275a0 |
| Popis: | Since the enkephalins were first isolated a number of opioid peptides have been discovered, including a heptapeptide with the sequence Tyr-Gly-Gly-Phe-Met-Arg-Phe (Met-enkephalin-Arg6-Phe7). The heptapeptide was first isolated from chromaffin granules in bovine adrenal medulla, but using immunochemical techniques it has now been identified in human, rat and bovine brains. The C-terminal tetrapeptide of this molecule (Phe-Met-Arg-Phe) occurs in amidated form as the molluscan peptide FMRFamide. Antisera raised against FMRFamide have revealed immunoreactive material in the brains of several vertebrate species, including the rat where it occurs in nerve cell bodies and terminals. I now report that ionophoretically applied FMRFamide has an excitatory effect on rat medullary neurones which is unaffected by the opiate antagonist naloxone. In contrast, Met-enkephalin-Arg6-Phe7 and leucine-enkephalin (Leu-enkephalin) have predominantly depressant effects, which suggests that FMRFamide acts at a separate receptor. |
| Databáze: | OpenAIRE |
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