Reductions in GABA following a tDCS-language intervention for primary progressive aphasia
| Autor: | Kyrana Tsapkini, Bronte Ficek, Kim Webster, Ashley D. Harris, Richard Ae Edden, Zeyi Wang |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Aging Language therapy Anodal tdcs Magnetic Resonance Spectroscopy Time Factors medicine.medical_treatment Transcranial Direct Current Stimulation Article Primary progressive aphasia 03 medical and health sciences 0302 clinical medicine Neuroplasticity medicine Humans Learning gamma-Aminobutyric Acid Aged Neuronal Plasticity Transcranial direct-current stimulation business.industry General Neuroscience Language intervention Middle Aged medicine.disease Aphasia Primary Progressive 030104 developmental biology Language Therapy Female Gabaergic inhibition Neurology (clinical) Geriatrics and Gerontology business Neuroscience 030217 neurology & neurosurgery Follow-Up Studies Developmental Biology |
| Zdroj: | Neurobiol Aging |
| ISSN: | 0197-4580 |
| DOI: | 10.1016/j.neurobiolaging.2019.03.011 |
| Popis: | Transcranial direct current stimulation (tDCS) has shown efficacy in augmenting the effects of language therapy in primary progressive aphasia (PPA). The mechanism of action of tDCS is not understood, but preliminary work in healthy adults suggests it modulates γ-aminobutyric acid (GABA) levels to create an environment optimal for learning. It is unknown if this proposed mechanism translates to aging or neurodegenerative conditions. This study tested the hypothesis that tDCS reduces GABA at the stimulated tissue in PPA. We applied GABA-edited magnetic resonance spectroscopy to quantify GABA levels before and after a sham-controlled tDCS intervention with language therapy in PPA. All participants showed improvements but those receiving active tDCS showed significantly greater language improvements compared to sham both immediately after the intervention and at 2-month follow-up. GABA levels in the targeted tissue decreased from baseline after the intervention and remained decreased 2 months after the intervention. This work supports the hypothesis that tDCS modulates GABAergic inhibition to augment learning and is clinically useful for PPA combined with language therapy. |
| Databáze: | OpenAIRE |
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