TACI Expression and Signaling in Chronic Lymphocytic Leukemia
| Autor: | Maria Kompoti, Anastasios E. Germenis, Maria Palassopoulou, Antigoni Mamara, Eudokia Mandala, Matthaios Speletas, Anastasia Banti, Nikolaos Giannakoulas |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
Adult Male Article Subject Transmembrane Activator and CAML Interactor Protein Cellular differentiation Chronic lymphocytic leukemia Tumor Necrosis Factor Ligand Superfamily Member 13 Immunology Paraproteinemias CD11c Apoptosis Biology Immunoglobulin G Cell surface receptor immune system diseases hemic and lymphatic diseases B-Cell Activating Factor medicine Humans Immunology and Allergy RNA Messenger B-cell activating factor Aged Aged 80 and over B-Lymphocytes Cell Differentiation General Medicine Middle Aged medicine.disease Leukemia Lymphocytic Chronic B-Cell Phenotype CD11c Antigen Immunoglobulin A Immunoglobulin M biology.protein Female Signal transduction lcsh:RC581-607 Research Article Signal Transduction |
| Zdroj: | Journal of Immunology Research Journal of Immunology Research, Vol 2015 (2015) |
| ISSN: | 2314-8861 |
| DOI: | 10.1155/2015/478753 |
| Popis: | TACI is a membrane receptor of BAFF and APRIL, contributing to the differentiation and survival of normal B cells. Although malignant B cells are also subjected on TACI signaling, there is a remarkable intradisease and interindividual variability of TACI expression in B-cell malignancies. The aim of our study was to explore the possible role of TACI signaling in the biology of chronic lymphocytic leukemia (CLL), including its phenotypic and clinical characteristics and prognosis. Ninety-four patients and 19 healthy controls were studied. CLL patients exhibited variable TACI expression, with the majority of cases displaying low to undetectable TACI, along with low to undetectable BAFF and increased APRIL serum levels compared to healthy controls. CLL cells with high TACI expression displayed a better survival capacity in vitro, when cultured with BAFF and/or APRIL. Moreover, TACI expression was positively correlated with the presence of monoclonal gammopathy and inversely with CD11c expression. Therefore, our study provides further evidence for the contribution of BAFF/APRIL signaling to CLL biology, suggesting also that TACI detection might be useful in the selection of patients for novel targeting therapeutic approaches. |
| Databáze: | OpenAIRE |
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