Pan-cancer analysis of RNA expression of ANGIOTENSIN-I-CONVERTING ENZYME 2 reveals high variability and possible impact on COVID-19 clinical outcomes
| Autor: | W. Michael Korn, Andrew Elliott, Phillip Stafford, Misako Nagasaka, David Spetzler, Jia Zeng, Lee S. Schwartzberg, Joanne Xiu, Michelle Saul, John L. Marshall, Jim Abraham, Heinz-Josef Lenz, Edward S. Kim |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Proteases Science Cell Biology TMPRSS2 Virus Article Neoplasms Virology Gene expression Exome Sequencing medicine Tumor Microenvironment Cancer genomics Humans Aged Tumor microenvironment Multidisciplinary Serine Endopeptidases Case-control study Cancer COVID-19 Middle Aged medicine.disease medicine.anatomical_structure Case-Control Studies Cancer research Medicine RNA Female Angiotensin-Converting Enzyme 2 |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Patients with cancer demonstrate particularly poor outcomes from COVID-19. To provide information essential for understanding the biologic underpinnings of this association, we analyzed whole-transcriptome RNA expression data obtained from a large cohort of cancer patients to characterize expression of ACE2, TMPRSS2, and other proteases that are involved in viral attachment to and entry into target cells. We find substantial variability of expression of these factors across tumor types and identify subpopulations expressing ACE2 at very high levels. In some tumor types, especially in gastrointestinal cancers, expression of ACE2 and TMPRSS2 is highly correlated. Furthermore, we found infiltration with T-cell and natural killer (NK) cell infiltration to be particularly pronounced in ACE2-high tumors. These findings suggest that subsets of cancer patients exist with gene expression profiles that may be associated with heightened susceptibility to SARS-CoV-2 infection, in whom malignant tumors function as viral reservoir and possibly promote the frequently detrimental hyper-immune response in patients infected with this virus. |
| Databáze: | OpenAIRE |
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