Gum Acacia mitigates diclofenac nephrotoxicity by targeting monocyte chemoattractant protein-1, complement receptor-1 and pro-apoptotic pathways
| Autor: | Amr El-Karef, Faten Shafeek, Nashwa M Abu-Elsaad, Tarek Ibrahim |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Diclofenac Complement receptor 1 Interleukin-1beta Apoptosis Complement receptor Pharmacology Toxicology Kidney Antioxidants Monocytes Nephropathy Nephrotoxicity 03 medical and health sciences Gum Arabic 0404 agricultural biotechnology Fibrosis Gum acacia medicine Animals Rats Wistar Chemokine CCL2 030304 developmental biology 0303 health sciences biology business.industry Tumor Necrosis Factor-alpha Anti-Inflammatory Agents Non-Steroidal Acute kidney injury 04 agricultural and veterinary sciences General Medicine Acute Kidney Injury medicine.disease biology.organism_classification 040401 food science Rats Receptors Complement medicine.anatomical_structure biology.gene business Biomarkers Food Science |
| Zdroj: | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 129 |
| ISSN: | 1873-6351 |
| Popis: | Treatment of many inflammatory diseases involves a chronic use of NSAIDs in large doses increasing acute kidney injury risk. This study was designed to evaluate a potential renoprotective effect of Gum Acacia (GA) on diclofenac (DICF) induced nephrotoxicity. Six groups of rats were used: normal group; control group (deprived from water during week 13), DICF group (deprived from water during week 13 and injected DICF i.p. 15 mg/kg/12 h at days 4 through 6 of water deprivation days, GA groups (1, 2 or 3 g/kg/day in drinking water) for 12 weeks followed by water deprivation and DICF injection as described. Kidney function, oxidative stress and anti-oxidant biomarkers were measured. Interleukin-1β, IL-10, TNF-α, complement receptor (CR)-1, monocyte chemoattractant protein (MCP)-1 and caspase-3 were assessed. Kidney sections were scored for fibrosis, tubular injury and inflammatory cells. An elevation in renal biomarkers, inflammatory cytokines, malondialdehyde and apoptotic markers was observed after DICF injection (p |
| Databáze: | OpenAIRE |
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