Sympathetic nervous activity and hemoglobin levels in de novo Parkinson's disease
| Autor: | Yasuyuki Iguchi, Atsuo Nakahara, Hiromasa Matsuno, Shusaku Omoto, Takeo Sato, Hisayoshi Oka, Hidetomo Murakami, Teppei Komatsu, Tomotaka Shiraishi, Tadashi Umehara |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Neurology Parkinson's disease Sympathetic Nervous System Anemia Orthostatic intolerance 030204 cardiovascular system & hematology 03 medical and health sciences Orthostatic vital signs Norepinephrine Hemoglobins Hypotension Orthostatic 0302 clinical medicine Internal medicine medicine Humans Aged Denervation Endocrine and Autonomic Systems business.industry Parkinson Disease medicine.disease 3-Iodobenzylguanidine Blood pressure Endocrinology Female Neurology (clinical) business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Clinical autonomic research : official journal of the Clinical Autonomic Research Society. 30(3) |
| ISSN: | 1619-1560 |
| Popis: | Sympathetic nervous denervation may be associated with the development of anemia. We aimed to investigate the association between sympathetic nervous denervation and hemoglobin levels in patients with Parkinson’s disease (PD). As indices of sympathetic nervous denervation, we investigated resting norepinephrine levels, increased norepinephrine levels after tilt-up, cardiac uptake of 123I-metaiodobenzylguanidine, supine blood pressure, and the degree of orthostatic hypotension in 132 patients with de novo PD. Older age, female sex, severe motor dysfunction, and lower body mass index were associated with decreased hemoglobin levels. After adjustment for these covariables, resting norepinephrine levels were negatively associated with hemoglobin levels. Hemoglobin levels were not associated with cardiac sympathetic denervation or orthostatic intolerance. Hemoglobin levels in PD seem to be closely related to noradrenergic nervous activity and nigrostriatal dopaminergic degeneration. In contrast to expectations, decreased hemoglobin levels were associated with increased whole-body sympathetic nervous activity in PD. |
| Databáze: | OpenAIRE |
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