Freeze-drying of silica nanoparticles: redispersibility toward nanomedicine applications
| Autor: | Larissa Fernanda Ferreira, Gabriela Borba Mondo, Agustín S. Picco, Mateus Borba Cardoso, Michelle S. Liberato |
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| Rok vydání: | 2017 |
| Předmět: |
Materials science
Silicon dioxide Scanning electron microscope Surface Properties Drug Compounding Biomedical Engineering Carbohydrates Medicine (miscellaneous) Nanoparticle Bioengineering 02 engineering and technology Development 010402 general chemistry 01 natural sciences Freeze-drying chemistry.chemical_compound Dynamic light scattering Drug Stability Desorption Humans General Materials Science Particle Size 021001 nanoscience & nanotechnology Silicon Dioxide Dynamic Light Scattering 0104 chemical sciences Freeze Drying Nanomedicine chemistry Chemical engineering Solubility Nanoparticles Particle size Powders 0210 nano-technology |
| Zdroj: | Nanomedicine (London, England). 13(2) |
| ISSN: | 1748-6963 |
| Popis: | Aim: To study freeze-drying of silica nanoparticles (SiO2NPs) in order to find suitable conditions to produce lyophilized powders with no aggregation after resuspension and storage. Methods: SiO2NPs were synthesized using a Stöber-based procedure, and characterized by scanning electron microscopy, dynamic light scattering and nitrogen adsorption/desorption isotherms. SiO2NPs hydrodynamic diameters were compared prior and after freeze-drying in the presence/absence of carbohydrate protectants. Results: Glucose was found to be the most suitable protectant against the detrimental effects of lyophilization. The minimum concentration of carbohydrate required to effectively protect SiO2NPs from aggregation during freeze-drying is influenced by the nanoparticle's size and texture. Negligible aggregation was observed during storage. Conclusion: Carbohydrates can be used during SiO2NPs freeze-drying process to obtain redispersable solids that maintain original sizes without residual aggregation. |
| Databáze: | OpenAIRE |
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