Associations of preconception exposure to air pollution and greenness with offspring asthma and hay fever
| Autor: | Joachim Heinrich, Ingrid Nordeide Kuiper, Randi Jacobsen Bertelsen, Christer Janson, Kees de Hoogh, Thomas Halvorsen, Ole Hertel, Lennart Bråbäck, Jesper H. Christensen, Simone Accordini, Cecilie Svanes, Torben Sigsgaard, Alessandro Marcon, Bertil Forsberg, Gerard Hoek, Iana Markevych, Mathias Holm, Ane Johannessen, A. Malinovschi |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
air pollution
childhood asthma childhood hay fever greenness preconception exposure Male Allergy Health Toxicology and Mutagenesis Respiratory Medicine and Allergy lcsh:Medicine 010501 environmental sciences Logistic regression 01 natural sciences 0302 clinical medicine Pregnancy 030212 general & internal medicine Child Lungmedicin och allergi Air Pollutants 3. Good health Europe Child Preschool Paternal Exposure Hay fever Female Maternal Inheritance Adolescent Offspring Nitrogen Dioxide Environment Article 03 medical and health sciences Arbetsmedicin och miljömedicin medicine Humans 0105 earth and related environmental sciences Asthma business.industry lcsh:R Public Health Environmental and Occupational Health Australia Infant Newborn Infant Rhinitis Allergic Seasonal Odds ratio Occupational Health and Environmental Health Environmental Exposure medicine.disease Preconception Injuries 13. Climate action Spain Particulate Matter business Demography |
| Zdroj: | International Journal of Environmental Research and Public Health (IJERPH) International Journal of Environmental Research and Public Health Volume 17 Issue 16 Kuiper, I N, Markevych, I, Accordini, S, Bertelsen, R J, Bråbäck, L, Christensen, J H, Forsberg, B, Halvorsen, T, Heinrich, J, Hertel, O, Hoek, G, Holm, M, de Hoogh, K, Janson, C, Malinovschi, A, Marcon, A, Sigsgaard, T, Svanes, C & Johannessen, A 2020, ' Associations of Preconception Exposure to Air Pollution and Greenness with Offspring Asthma and Hay Fever ', International Journal of Environmental Research and Public Health, vol. 17, no. 16, 5828 . https://doi.org/10.3390/ijerph17165828 International Journal of Environmental Research and Public Health, Vol 17, Iss 5828, p 5828 (2020) |
| Popis: | We investigated if greenness and air pollution exposure in parents&rsquo childhood affect offspring asthma and hay fever, and if effects were mediated through parental asthma, pregnancy greenness/pollution exposure, and offspring exposure. We analysed 1106 parents with 1949 offspring (mean age 35 and 6) from the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) generation study. Mean particulate matter (PM2.5 and PM10), nitrogen dioxide (NO2), black carbon (BC), ozone (O3) (µ g/m3) and greenness (normalized difference vegetation index (NDVI)) were calculated for parents 0&ndash 18 years old and offspring 0&ndash 10 years old, and were categorised in tertiles. We performed logistic regression and mediation analyses for two-pollutant models (clustered by family and centre, stratified by parental lines, and adjusted for grandparental asthma and education). Maternal medium PM2.5 and PM10 exposure was associated with higher offspring asthma risk (odds ratio (OR) 2.23, 95%CI 1.32&ndash 3.78, OR 2.27, 95%CI 1.36&ndash 3.80), and paternal high BC exposure with lower asthma risk (OR 0.31, 95%CI 0.11&ndash 0.87). Hay fever risk increased for offspring of fathers with medium O3 exposure (OR 4.15, 95%CI 1.28&ndash 13.50) and mothers with high PM10 exposure (OR 2.66, 95%CI 1.19&ndash 5.91). The effect of maternal PM10 exposure on offspring asthma was direct, while for hay fever, it was mediated through exposures in pregnancy and offspring&rsquo s own exposures. Paternal O3 exposure had a direct effect on offspring hay fever. To conclude, parental exposure to air pollution appears to influence the risk of asthma and allergies in future offspring. |
| Databáze: | OpenAIRE |
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