Isolation of highly pathogenic H5N6 avian influenza virus in Southern Vietnam with genetic similarity to those infecting humans in China

Autor:	Momoko Nakayama, Ryota Tsunekuni, Kasumi Sudo, Nobuhiro Takemae, Phuong Thanh Nguyen, Tran Minh Tan, Junki Mine, Taichiro Tanikawa, Thai Duy Phuong, Kirill Sharshov, Takehiko Saito, Tung T. Nguyen, Bach Duc Luu
Rok vydání:	2019
Předmět:	China 040301 veterinary sciences animal diseases Highly pathogenic Biology medicine.disease_cause Genome 0403 veterinary science 03 medical and health sciences Genetic similarity Influenza Human medicine Animals Humans Phylogeny 030304 developmental biology 0303 health sciences Avian influenza virus General Veterinary General Immunology and Microbiology Phylogenetic tree virus diseases Outbreak 04 agricultural and veterinary sciences General Medicine Virology Influenza A virus subtype H5N1 Ducks Amino Acid Substitution Vietnam Influenza A virus Influenza in Birds Sequence Analysis Reassortant Viruses
Zdroj:	SC30202003110011 NARO成果DBd C30201908060001_7504
ISSN:	1865-1682 1865-1674
Popis:	Since 2013, H5N6 highly pathogenic avian influenza viruses (HPAIVs) have been responsible for outbreaks in poultry and wild birds around Asia. H5N6 HPAIV is also a public concern due to sporadic human infections being reported in China. In the current study, we isolated an H5N6 HPAIV strain (A/Muscovy duck/Long An/AI470/2018; AI470) from an outbreak at a Muscovy duck farm in Long An Province in Southern Vietnam in July 2018 and genetically characterized it. Basic Local Alignment Search Tool (BLAST) analysis revealed that the eight genomic segments of AI470 were most closely related (99.6%-99.9%) to A/common gull/Saratov/1676/2018 (H5N6), which was isolated in October 2018 in Russia. Furthermore, AI470 also shared 99.4%-99.9% homology with A/Guangxi/32797/2018, an H5N6 HPAIV strain that infected humans in China in 2018. Phylogenetic analyses of the entire genome showed that AI470 was directly derived from H5N6 HPAIVs that were in South China from 2015 to 2018 and clustered with four H5N6 HPAIV strains of human origin in South China from 2017 to 2018. This indicated that AI470 was introduced into Vietnam from China. In addition, molecular characteristics related to mammalian adaptation among the recent human H5N6 HPAIV viruses, except PB2 E627K, were shared by AI470. These findings are cause for concern since H5N6 HPAIV strains that possess a risk of human infection have crossed the Chinese border.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::870b3d07c05663b6fa0d92c77684eb2d https://doi.org/10.1111/tbed.13294 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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