HLA-DRB1 leprogenic motifs in nigerian population groups
| Autor: | Patricia A. Fraser, Wei-Zi Ding, L. Y Lu, M. A Asuquo, Adewole T, G.P. Uko, Dolores A. Fici, U Umana, E. R Udim, Mahan S, Zuheir L. Awdeh |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Adolescent Immunology Amino Acid Motifs Nigeria Peptide binding Epitope Epitopes Gene Frequency Leprosy medicine Immunology and Allergy Humans Allele Mycobacterium leprae HLA-DRB1 HLA Complex Alleles Aged Genetics Binding Sites biology Histocompatibility Testing T-cell receptor HLA-DR Antigens Original Articles Middle Aged biology.organism_classification medicine.disease Female HLA-DRB1 Chains |
| Zdroj: | Clinical and experimental immunology. 118(1) |
| ISSN: | 0009-9104 |
| Popis: | SUMMARYAmino acid residues involved in the peptide binding groove of HLA-DRB1 alleles were examined in three Nigerian ethnic groups with leprosy (n = 287) and 170 controls to determine the role of DRB1 alleles in disease outcome with Mycobacterium leprae. Nine positively charged motifs and two others with neutral charge to the binding groove were detected. These motifs occurred more frequently in leprosy (leprogenic) than was expected by chance (P |
| Databáze: | OpenAIRE |
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