Myocardial Protection in Donor Heart Preservation: A Comparison Between Bretschneider's Histidine–Tryptophan–Ketoglutarate Solution and Cold Blood Cardioplegia
| Autor: | Po-Shun Hsu, Chih-Hong Kao, Yi-Ting Tsai, Chien-Sung Tsai, Shih-Ying Sung, Chung-Yi Lee, Ying-Chung Lin, Chin Lin, Jenn-Yeu Song |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Inotrope Time Factors medicine.medical_treatment Organ Preservation Solutions Taiwan Hemodynamics Myocardial Reperfusion Injury Hospitals General Ventricular Function Left Potassium Chloride Risk Factors Intensive care medicine Humans Mannitol Cardioplegic Solutions Retrospective Studies Heart Failure Heart transplantation Transplantation Chi-Square Distribution business.industry Stroke Volume Retrospective cohort study Organ Preservation Perioperative Length of Stay Middle Aged Myocardial Contraction Cold Temperature Intensive Care Units Glucose Treatment Outcome Donor heart Anesthesia Multivariate Analysis Heart Arrest Induced Tissue and Organ Harvesting Heart Transplantation Female Surgery business Chi-squared distribution Procaine |
| Zdroj: | Transplantation Proceedings. 46:1077-1081 |
| ISSN: | 0041-1345 |
| DOI: | 10.1016/j.transproceed.2013.11.056 |
| Popis: | Background Optimal myocardial protection for donated hearts is crucial to improve outcomes of heart transplantation and reduce morbidity and mortality. This study aimed to compare the efficacy of myocardial protection using single dose of Bretschneider's histidine–tryptophan–ketoglutarate (HTK) solution and repeated doses of cold blood cardioplegia (CBC) in donor heart preservation. Methods Sixty-seven patients undergoing heart transplantation in Tri-Service General Hospital, Taipei, Taiwan between 2002 and 2012 were enrolled in this study. Patients were divided into an HTK group and a CBC group based on the preservation solution used to protect the donated hearts. The perioperative variables and postoperative outcomes were retrospectively reviewed. Results There were no statistic differences about demographic data in donors and recipients between the 2 groups. There were no significant differences in postoperative cardiac enzymes, hemodynamic data, length of stay in intensive care, or 30-day mortality between the groups. The HTK group showed a trend of shorter pumping time (P = .091). Multivariate analyses reveal that the HTK group had higher postoperative inotropic score (P Conclusions Single dose of Bretschneider's HTK solution could effectively reduce pumping time and afford similar myocardial protection compared with repeated doses of CBC in the preservation of donated hearts. |
| Databáze: | OpenAIRE |
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