Comparison of cystatin C and creatinine-based glomerular filtration rate formulas with 51Cr-EDTA clearance in patients with cirrhosis
| Autor: | Devaki Nair, Andrew K. Burroughs, Mark Hajjawi, Pinelopi Manousou, Evangelos Cholongitas, Elias Xirouchakis, Michael B. Thomas, Gian Piero Guerrini, Andrew Kerry, M. Pleguezuelo, Sergio Maimone, Laura Marelli, Vincenza Calvaruso, David Patch |
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| Přispěvatelé: | Xirouchakis, E, Marelli, L, Cholongitas, E, Manousou, P, Calvaruso, V, Pleguezuelo, M, Guerrini, GP, Maimone, S, Kerry, A, Hajjawi, M, Nair, D, Thomas, M, Patch, D, Burroughs, AK |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Cirrhosis Bilirubin Epidemiology medicine.medical_treatment Urology Renal function Liver transplantation urologic and male genital diseases Critical Care and Intensive Care Medicine Aged Aged 80 and over Creatinine Cystatin C Female Humans Middle Aged Multivariate Analysis Chromium Radioisotopes Edetic Acid Glomerular Filtration Rate Nephrology Transplantation chemistry.chemical_compound Bayesian multivariate linear regression Internal medicine 80 and over Medicine biology business.industry cirrhosis Original Articles 51cr edta clearance medicine.disease Endocrinology chemistry biology.protein business |
| Popis: | Renal function is an important predictor of survival in cirrhosis and liver transplantation. GFR estimates using serum cystatin C (CysC) are proposed as better predictors of renal function than ones on the basis of serum creatinine (Cr). Our aims were: (1) evaluate correlations between serum CysC and different methods of creatinine measurements; (2) compare CysC and Cr GFR formulas with (51)Cr-EDTA; and (3) evaluate liver-related parameters potentially influencing GFR.254 blood samples in 65 patients with cirrhosis correlating CysC with four Cr methods were used; another 74 patients comparing (51)Cr-EDTA GFR to Modification of Diet in Renal Disease and Larsson and Hoek formulas for CysC were also included. Agreement was assessed using Bland-Altman plots and concordance correlation coefficients. Multivariate linear regression analysis was used for GFR predictors.Serum CysC correlated modestly with O'Leary modified Jaffe, compensated kinetic Jaffe, enzymatic creatinine, and standard kinetic Jaffe 0.72/0.71/0.72/0.72 (all P0.001). Bland-Altman agreement with (51)Cr-EDTA GFR was poor; the best agreement was Modification of Diet in Renal Disease (concordance 0.61; 95% CI, 0.47 to 0.71); the worst agreement was the Hoek formula (concordance 0.46; 95% CI, 0.27 to 0.61). A new GFR formula including the Child-Pugh score improved the accuracy of Cr GFR formulas compared with (51)Cr-EDTA GFR.Estimated GFR in cirrhosis is not better with CysC formulas compared with creatinine ones: specific formulas may be necessary. |
| Databáze: | OpenAIRE |
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