Clinical and prognostic profile of Her2neu positive (non-luminal) intrinsic breast cancer subtype: comparison with Her2neu positive luminal breast cancers

Autor: Narisa Iftikhar, Saadia Mehmood Khan, Naveen Faridi, Amir Khan, Atif Ali Hashmi, Mariam Nisar, Muhammad Muzzammil Edhi, Raeesa Mahboob, Muhammad Irfan, Maham Siddiqui
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Oncology
Adult
medicine.medical_specialty
Proliferative index
Receptor
ErbB-2
Population
lcsh:Medicine
Breast Neoplasms
Intrinsic breast cancer
Proto-Oncogene Mas
General Biochemistry
Genetics and Molecular Biology
PR
03 medical and health sciences
Tumor grade
0302 clinical medicine
Breast cancer
Internal medicine
mental disorders
medicine
Biomarkers
Tumor
Humans
education
Receptor
lcsh:Science (General)
lcsh:QH301-705.5
education.field_of_study
business.industry
lcsh:R
Breast cancer subtype
General Medicine
Middle Aged
medicine.disease
Prognosis
Predictive value
Research Note
030104 developmental biology
Ki-67 Antigen
lcsh:Biology (General)
Her2neu
ER
Receptors
Estrogen
030220 oncology & carcinogenesis
Ki67 index
Female
business
Receptors
Progesterone
psychological phenomena and processes
lcsh:Q1-390
Zdroj: BMC Research Notes
BMC Research Notes, Vol 11, Iss 1, Pp 1-6 (2018)
ISSN: 1756-0500
Popis: Objective Her2neu receptor is proto-oncogene which can be over-expressed in both luminal and non-luminal breast cancers. In the present study, we aimed to compare the prognostic and predictive factors like tumor grade, T-stage, N-stage and ki67 index in Her2neu intrinsic breast cancer subtype with Her2neu over-expressed luminal breast cancers. Results 801 (41%) cases were Her2neu positive; out of which, 418 cases (52.2%) showed ER positivity and thus were classified as Her2neu positive luminal cancers whereas 383 cases (47.8%) were ER and PR negative and therefore were labeled as intrinsic Her2neu subtype (non-luminal). Her2neu positive (non-luminal) cancers were significantly associated with higher grades and Ki67 proliferative index compared to Her2neu positive luminal cancers. On the other no significant association was noted in T-stage and N-stage. We found a high frequency of her2neu positivity in our studied population of breast cancer. Moreover, association of her2neu positive (non-luminal) breast cancers with higher grade and ki67 index indicates a predictive value of ER/PR positivity in her2neu positive breast cancers. On the other hand, lack of association with respect to T and N stage, signifies no prognostic benefit of ER/PR in her2neu positive breast cancers.
Databáze: OpenAIRE
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