Beraprost, a stable analog of prostacyclin, enhances cough reflex sensitivity to capsaicin in bronchitic patients

Autor:	Noriyuki Ohkura, Johsuke Hara, Hideko Ikeda, Kazuo Kasahara, Masaki Fujimura, Yasutaka Shiba, Yoshihisa Ishiura
Rok vydání:	2014
Předmět:	Male Pulmonary and Respiratory Medicine Chronic bronchitis Neutrophils Cough reflex Vital Capacity Clinical Biochemistry Administration Oral Prostacyclin Pharmacology Bronchial Provocation Tests chemistry.chemical_compound Forced Expiratory Volume Administration Inhalation medicine Humans Molecular Biology Aged Aged 80 and over Cross-Over Studies Productive Cough Dose-Response Relationship Drug business.industry Middle Aged Epoprostenol Crossover study Pathophysiology respiratory tract diseases Beraprost Bronchitis Chronic Cough chemistry Capsaicin Anesthesia Female business medicine.drug
Zdroj:	Experimental Lung Research. 40:495-499
ISSN:	1521-0499 0190-2148
Popis:	Inflammatory mediators are involved in the pathophysiology of neutrophilic bronchial disorders presenting with chronic productive cough. Accumulating evidence indicates that prostanoids are key elements in the pathophysiology of these disorders. However, little is known about the role of prostacyclin in neutrophilic bronchial inflammation.The effect of beraprost, a chemically and biologically stable analog of prostacyclin, on cough response to inhaled capsaicin was examined in 14 patients with chronic bronchitis, a neutrophilic bronchial disorder, in a randomized, placebo-controlled crossover study. Capsaicin cough threshold, defined as the lowest concentration of capsaicin eliciting five or more coughs, was measured as an index of the airway cough reflex sensitivity.After a 2-week treatment with beraprost (80 μg twice a day orally), the cough threshold was significantly (P.05) decreased as compared with placebo [12.2 (geometric standard error of the mean [GSEM] 1.5) μM vs. 24.4 (GSEM 1.3)].These findings indicate that prostacyclin is involved in the pathophysiology of cough reflex sensitivity in patients with chronic bronchitis, a frequently encountered neutrophilic bronchial disorder presenting with chronic productive cough.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::870752950e8bccb7ec9ddacbada2c962 https://doi.org/10.3109/01902148.2014.946632 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.