Dopaminergic inhibition of pituitary beta-endorphin-like immunoreactivity secretion in the rat
| Autor: | Gregory P. Mueller, John M. Farah, Diana S. Malcolm |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Male
medicine.medical_specialty Pituitary gland Pharmacology Receptors Dopamine Endocrinology Dopamine Internal medicine Dopamine receptor D2 medicine Animals Endorphins Pergolide Chemistry Dopaminergic Pimozide beta-Endorphin Rats Inbred Strains Bromocriptine Prolactin Rats medicine.anatomical_structure Dopamine receptor Pituitary Gland Haloperidol medicine.drug |
| Zdroj: | Endocrinology. 110(2) |
| ISSN: | 0013-7227 |
| Popis: | A pharmacologic approach was used to examine the possible role of dopamine neurons in the regulation of pituitary beta-endorphin-like immunoreactivity (beta-END-LI) secretion in the rat. Blockade of dopamine receptors by haloperidol or pimozide treatment evoked dose- and time-related increases in plasma levels of beta-END-LI. Physical immobilization increased circulating beta-END-LI six-fold and pretreatment with dopamine receptor agonists (bromocriptine or pergolide) significantly attenuated this rise without affecting plasma beta-END-LI levels in non-stressed animals. Dopaminergic drugs and immobilization produced similar effects on circulating PRL as on beta-END-LI. However, the magnitude of change in levels of PRL was generally greater than the change in beta-END-LI. The present findings suggest that dopaminergic neurons inhibit the release of pituitary beta-END-LI as well as PRL in the rat. |
| Databáze: | OpenAIRE |
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