Insulin Resistance in Cushing's Disease: Evaluation by Studies of Insulin Binding to Erythrocytes
| Autor: | Bernardo L Wajchenberg, Carlos E Leme, Antonio C Lerario, Iracelia T Toledo, E Souza, Helena W Rodbard, David Rodbard |
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| Rok vydání: | 1984 |
| Předmět: |
Adult
Blood Glucose medicine.medical_specialty Erythrocytes Adolescent Endocrinology Diabetes and Metabolism medicine.medical_treatment Cushing syndrome Insulin resistance Internal medicine Internal Medicine medicine Humans Insulin Obesity Child Receptor Cushing Syndrome biology Cushing's disease Middle Aged medicine.disease Receptor Insulin Insulin receptor Endocrinology biology.protein Female Insulin Resistance Glucocorticoid medicine.drug |
| Zdroj: | Diabetes. 33:455-459 |
| ISSN: | 1939-327X 0012-1797 |
| Popis: | Studies of 125I-insulin binding to erythrocytes (RBC) from 5 patients with Cushing's disease were performed in an attempt to evaluate the insulin resistance in this disease. Five obese, nondiabetic patients and six normal subjects served as controls. Insulin resistance was present in both the obese, nondiabetic subjects and in the patients with Cushing's disease. Patients with Cushing's disease showed insulin resistance out of proportion to obesity, and of greater severity than in the obese subjects. As in previous studies, the insulin resistance of the obese subjects could be at least partially ascribed to a reduced number of receptors. In contrast, in our patients with Cushing's disease, no physiologically significant changes in the parameters of insulin-receptor interaction could be demonstrated. This suggests that the RBC insulin receptor is not involved in this type of insulin resistance. |
| Databáze: | OpenAIRE |
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