Clinical Outcomes of Penetrating Keratoplasty and Descemet Stripping Automated Endothelial Keratoplasty in Asian Population with American Corneas
| Autor: | Hsin-Yuan Tan, Po-Yuan Chen, Hsin-Chiung Lin, Lung-Kun Yeh, Wei-Chi Wu, Yaa-Jyuhn James Meir, Fang-Chi Hsiao, David Hui-Kang Ma, Ching-Hsi Hsiao, Hung-Chi Chen |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty PK Descemet membrane Health Toxicology and Mutagenesis Corneal graft Visual Acuity lcsh:Medicine Article Corneal Diseases Cornea 03 medical and health sciences 0302 clinical medicine Asian People Ophthalmology medicine Humans DSAEK Survival rate 030304 developmental biology Aged Retrospective Studies long term clinical outcomes 0303 health sciences business.industry lcsh:R Significant difference Graft Survival Public Health Environmental and Occupational Health Middle Aged Descemet stripping automated endothelial keratoplasty Tissue Donors United States imported corneas Transplantation Treatment Outcome 030221 ophthalmology & optometry Asian population Female sense organs Complication business Descemet Stripping Endothelial Keratoplasty Keratoplasty Penetrating |
| Zdroj: | International Journal of Environmental Research and Public Health Volume 16 Issue 22 International Journal of Environmental Research and Public Health, Vol 16, Iss 22, p 4547 (2019) |
| ISSN: | 1660-4601 |
| DOI: | 10.3390/ijerph16224547 |
| Popis: | To determine the comparative efficacy and safety of penetrating keratoplasty (PK) and Descemet stripping automated endothelial keratoplasty (DSAEK) in the Asian population receiving imported donor corneas, our single-center retrospective study provides analysis supporting the transition from PK to DSAEK in the Asian population using imported American donor corneas. We analyzed 259 patients with 241 and 57 cases of PK and DSAEK respectively during 2008 to 2017 using imported corneas at Chang Gung Memorial Hospital, Linkou, Taiwan. In terms of long-term graft survival analysis, there was no difference between PK and DSAEK (log-rank p = 0.386, HR = 0.920, 95% CI: [0.641&ndash 1.380]). However, Cox proportional regression analysis revealed that corneal survival rate of DSAEK group in the first 100 days after transplantation was inferior than that of PK group (log-rank p < 0.001, HR = 2.733, 95% CI: [1.501&ndash 4.977])]. Despite the inferior survival rate, there were significantly less neovascularization and Descemet membrane folds in the DSAEK group. Importantly, the non-complication rate of DSAEK was much higher than that of PK with significant difference (PK, 25.7% vs DSAEK 42.0%, p = 0.022). Collectively, DSAEK is suggested as an alternative surgical modality in Asian patients using imported American donor corneas because of less complication, and no difference in long-term corneal graft survival rates between PK and DSAEK. |
| Databáze: | OpenAIRE |
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