Transient glutathione depletion in the substantia nigra compacta is associated with neuroinflammation in rats

Autor:	Sandra Orozco-Suárez, Nancy Pavón-Fuentes, Mei-Li Díaz-Hung, Alexis Díaz-García, Rilda Leon-Martinez, Lourdes Lorigados-Pedre, Luis Fernando Hernández-Zimbrón, Arianna Yglesias-Rivera, Jenny Laura Ruiz-Fuentes, Lisette Blanco-Lezcano
Rok vydání:	2016
Předmět:	Male 0301 basic medicine medicine.medical_specialty Substantia nigra Nitric oxide Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Animals Buthionine sulfoximine Buthionine Sulfoximine Neuroinflammation Inflammation Neurons biology Microglia Pars compacta General Neuroscience JNK Mitogen-Activated Protein Kinases Glutathione Corpus Striatum Substantia Nigra Nitric oxide synthase 030104 developmental biology medicine.anatomical_structure Endocrinology chemistry Biochemistry biology.protein 030217 neurology & neurosurgery
Zdroj:	Neuroscience. 335:207-220
ISSN:	0306-4522
Popis:	Glutathione (GSH) deficiency has been identified as an early event in the progression of Parkinson's disease. However, the role of GSH in the etiology and pathogenesis of this neurodegenerative disorder is not well established. The aim of this study is to assess the effect of transient GSH depletion in the substantia nigra pars compacta (SNpc) on neuroinflammation after the injection of a single dose of l-buthionine sulfoximine (BSO) into the SNpc of male Sprague-Dawley rats. The results showed that BSO treatment stimulates microglia (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8704a6f5e75973ce35d16312d42d27c1 https://doi.org/10.1016/j.neuroscience.2016.08.023 Zobrazit plný text záznamu Full Text from ScienceDirect