Alternative Synaptonemal Complex Structures: Too Much of a Good Thing?
| Autor: | R. Scott Hawley, Stacie E. Hughes |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Crossover
Biology Lateral element Chromosome segregation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Meiosis Chromosome Segregation Genetics Homologous chromosome Animals Humans Crossing Over Genetic 030304 developmental biology 0303 health sciences Synaptonemal Complex Nuclear Proteins Cell biology Chromosome Pairing Synaptonemal complex chemistry 030217 neurology & neurosurgery DNA Recombination |
| Zdroj: | Trends in Genetics. 36:833-844 |
| ISSN: | 0168-9525 |
| DOI: | 10.1016/j.tig.2020.07.007 |
| Popis: | The synaptonemal complex (SC), a highly conserved structure built between homologous meiotic chromosomes, is required for crossover formation and ensuring proper chromosome segregation. In many organisms, SC components can also form alternative structures, including repeating SC structures that are known as polycomplexes (PCs), and extensively modified SC structures that are maintained late in meiosis. PCs display differences in their ability to localize with lateral element proteins, recombination machinery, and DNA. They can be created by defects in post-translational modification, suggesting that these modifications have roles in preventing alternate SC structures. These SC-like structures provide insight into the rules for building and maintaining the SC by offering an 'in vivo laboratory' for models of SC assembly, structure, and disassembly. Here, we discuss what these structures can tell us about the rules for building the SC and the roles of the SC in meiotic processes. |
| Databáze: | OpenAIRE |
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