Suppressors of cancer cell proliferation from fig (Ficus carica) resin: isolation and structure elucidation

Autor:	Yoel Kashman, Ruth Rabinowitz, Shai Rubnov, Raphael Mechoulam, Michael Schlesinger
Rok vydání:	2001
Předmět:	Male Magnetic Resonance Spectroscopy Latex Lymphoma Stereochemistry Pharmaceutical Science Mammary Neoplasms Animal Pharmacognosy Chemical synthesis Mass Spectrometry Analytical Chemistry Glucosides Drug Discovery Tumor Cells Cultured Humans Cytotoxicity Chromatography High Pressure Liquid Pharmacology chemistry.chemical_classification Leukemia Plants Medicinal biology Organic Chemistry Glycoside Prostatic Neoplasms biology.organism_classification Moraceae Antineoplastic Agents Phytogenic Sitosterols In vitro Complementary and alternative medicine Biochemistry chemistry Fruit Saturated fatty acid Molecular Medicine lipids (amino acids peptides and proteins) Female Chromatography Thin Layer Soybeans Carica
Zdroj:	Journal of natural products. 64(7)
ISSN:	0163-3864
Popis:	A mixture of 6-O-acyl-beta-D-glucosyl-beta-sitosterols, the acyl moeity being primarily palmitoyl and linoleyl with minor amounts of stearyl and oleyl, has been isolated as a potent cytotoxic agent from fig (Ficuscarica) latex and soybeans. Identity was established by spectroscopic methods (NMR, MS) and confirmed by chemical synthesis. Both the natural and the synthetic compounds showed in vitro inhibitory effects on proliferation of various cancer cell lines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87024f4ad52972c99640e3b0384681d5 https://pubmed.ncbi.nlm.nih.gov/11473446 Zobrazit plný text záznamu