Preeclampsia/Eclampsia candidate genes show altered methylation in maternal leukocytes of preeclamptic women at the time of delivery
| Autor: | Vesna D. Garovic, Brian C. Brost, Carl H. Rose, Kristi S. Borowski, Wendy M. White, Norman Davies, Zhifu Sun |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
0301 basic medicine Candidate gene Pro-Opiomelanocortin Calcitonin Gene-Related Peptide Angiotensinogen Bioinformatics Article Amidohydrolases Preeclampsia Andrology Young Adult 03 medical and health sciences Pre-Eclampsia Pregnancy Leukocytes Internal Medicine Humans Medicine Eclampsia Epigenetics business.industry Gene Expression Profiling Parturition Obstetrics and Gynecology Methylation DNA Methylation medicine.disease Gene expression profiling 030104 developmental biology CpG site Case-Control Studies DNA methylation CpG Islands Female business |
| Zdroj: | Hypertension in Pregnancy. 35:394-404 |
| ISSN: | 1525-6065 1064-1955 |
| Popis: | Objective: To analyze methylation profiles of known preeclampsia/eclampsia (PE) candidate genes in normal (NL) and preeclamptic (PE) women at delivery. Methods: A matched case–control study comparing methylation in 79 CpG sites/33 genes from an independent gene set in maternal leukocyte DNA in PE and NL (n = 14 each) on an Illumina BeadChip platform. Replication performed on second cohort (PE = 12; NL = 32). Results: PE demonstrates differential methylation in POMC, AGT, CALCA, and DDAH1 compared with NL. Conclusion: Differential methylation in four genes associated with PE may represent a potential biomarker or an epigenetic pathophysiologic mechanism altering gene transcription. |
| Databáze: | OpenAIRE |
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