Pretransplant Cytomegalovirus-Specific Cellular Immunity and Risk of Viral Reactivation Following Lung Transplantation: A Prospective Cohort Study
| Autor: | Katie E. Lineburg, Rajiv Khanna, Debottam Sinha, Michelle A Neller, Pauline Crooks, Katherine K. Matthews, Michelle Grant, Mohammed Altaf, George R Ambalathingal, Peter Hopkins, Corey Smith, Sweera Rehan, Daniel C. Chambers |
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| Rok vydání: | 2020 |
| Předmět: |
Cellular immunity
medicine.medical_treatment Congenital cytomegalovirus infection 030230 surgery 03 medical and health sciences 0302 clinical medicine Immunity Humans Immunology and Allergy Medicine Lung transplantation Prospective Studies Prospective cohort study Immunity Cellular Viral reactivation Lung business.industry Incidence (epidemiology) virus diseases medicine.disease surgical procedures operative Infectious Diseases medicine.anatomical_structure Cytomegalovirus Infections Immunology Latent Infection 030211 gastroenterology & hepatology business Lung Transplantation |
| Zdroj: | The Journal of Infectious Diseases. 224:312-317 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/jiaa750 |
| Popis: | Cytomegalovirus (CMV) remains a significant burden in lung transplant recipients. Deficiencies in T-cell immunity posttransplant increase the risk of CMV-associated complications. However, it is not clear if underlying poor pretransplant immunity increases risk. To assess this, we recruited 39 prospective lung transplant patients and performed QuantiFERON-CMV on their peripheral blood. More than a third of prospective CMV-seropositive transplant recipients were CMV non-immune reactive (CMV-NIR) pretransplant. CMV-NIR status was associated with a significantly higher incidence of CMV reactivation posttransplant, demonstrating that dysfunctional CMV immunity in prospective lung transplant recipients is associated with an increased risk of viral reactivation posttransplant. |
| Databáze: | OpenAIRE |
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