The induction and potentiation of c-Jun and c-Fos expression in spinal neurons mediated by NK1 and NK2 receptors
| Autor: | Joanne Redburn, J.D. Leah |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Patch-Clamp Techniques Proto-Oncogene Proteins c-jun Stimulation Stimulus (physiology) c-Fos Peptides Cyclic Cellular and Molecular Neuroscience Endocrinology Neurokinin-1 Receptor Antagonists Piperidines Animals Rats Wistar Transcription factor Neurons biology Endocrine and Autonomic Systems c-jun Biphenyl Compounds Long-term potentiation General Medicine Receptors Neurokinin-2 Receptors Neurokinin-1 Sciatic Nerve Rats Electrophysiology Neurology Spinal Cord Benzamides biology.protein Antagonism Neuroscience Proto-Oncogene Proteins c-fos |
| Zdroj: | Neuropeptides. 33(2) |
| ISSN: | 0143-4179 |
| Popis: | Specific antagonists were used to determine NK1 and NK2 receptor mediation of the expression of c-Jun and c-Fos inducible transcription factors. (ITFs) in dorsal horn neurons. The induction of c-Jun by C-fiber stimulation was strongly reduced in the superficial laminae by NK1 and NK2 antagonists, but only weakly in the deep laminae by NK2 antagonism. c-Fos induction was reduced in all laminae by both NK1 and NK2 antagonism but less than with c-Jun. The potentiation of c-Jun expression, caused by a preceding stimulus, was abolished in all laminae by NK1 and NK2 antagonists, whereas that of c-Fos was reduced in all laminae but again less than that of c-Jun. Thus, the expressions of ITFs mediated by NK1 and NK2 receptors are complex, depending upon the neurons and stimulus considered, and they are not a measure of the neurons’ electrophysiological responsiveness. |
| Databáze: | OpenAIRE |
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