Biphenyl amide p38 kinase inhibitors 2: Optimisation and SAR

Autor:	Richard Martyn Angell, David W. Brown, Katherine Louise Jones, Smith Kathryn Jane, Ann Louise Walker, Penny A. Smee, Tim Longstaff, Paul Bamborough, Tony D. Angell, Stuart G. Cockerill, Chris D. Edwards, Don O. Somers, Murray J. B. Brown, Jacky B. Buckton, Malcolm Willson
Rok vydání:	2007
Předmět:	Models Molecular Stereochemistry p38 mitogen-activated protein kinases Clinical Biochemistry Biphenyl derivatives Molecular Conformation Pharmaceutical Science Administration Oral Non-specific serine/threonine protein kinase Crystallography X-Ray Biochemistry p38 Mitogen-Activated Protein Kinases Piperazines chemistry.chemical_compound Structure-Activity Relationship In vivo Amide Drug Discovery Animals Molecular Biology Protein Kinase Inhibitors chemistry.chemical_classification Biphenyl Oxadiazoles Organic Chemistry Biphenyl Compounds Amides Arthritis Experimental Rats Enzyme chemistry Molecular Medicine Protein Binding
Zdroj:	Bioorganicmedicinal chemistry letters. 18(1)
ISSN:	1464-3405
Popis:	The biphenyl amides are a novel series of p38 MAP kinase inhibitors. Structure–activity relationships of the series against p38α are discussed with reference to the X-ray crystal structure of an example. The series was optimised rapidly to a compound showing oral activity in an in vivo disease model.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86feebad65214ffc6c268e00b3237bb0 https://pubmed.ncbi.nlm.nih.gov/17981461 Zobrazit plný text záznamu Full Text from ScienceDirect