Targeting Glutamine Metabolism and PD-L1: A Novel Anti-tumor Pas de Deux
| Autor: | Naomi Taylor, Valerie Dardalhon, Maria I. Matias |
|---|---|
| Přispěvatelé: | Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Hematopoïèse et Immunothérapie, Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
SERCA
Glutamine Cell Glutamine metabolism MESH: NF-kappa B [SDV.CAN]Life Sciences [q-bio]/Cancer B7-H1 Antigen 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Immunity PD-L1 Neoplasms [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry Molecular Biology/Genomics [q-bio.GN] medicine MESH: B7-H1 Antigen Humans MESH: Neoplasms Molecular Biology 030304 developmental biology Antitumor activity 0303 health sciences MESH: Glutamine MESH: Humans biology NF-kappa B Cell Biology 3. Good health medicine.anatomical_structure biology.protein Cancer research 030217 neurology & neurosurgery |
| Zdroj: | Molecular Cell Molecular Cell, Elsevier, 2020, 80 (4), pp.555-557. ⟨10.1016/j.molcel.2020.11.005⟩ |
| ISSN: | 1097-2765 |
| DOI: | 10.1016/j.molcel.2020.11.005⟩ |
| Popis: | Refers toJun-Kyu Byun, Mihyang Park, Seunghyeong Lee, Jae Won Yun, Jaebon Lee, Jae Sun Kim, Sung Jin Cho, Hui-Jeon Jeon, In-Kyu Lee, Yeon-Kyung Choi, Keun-Gyu ParkInhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor ImmunityMolecular Cell, Volume 80, Issue 4, 19 November 2020, Pages 592-606.e8; International audience; In this issue of Molecular Cell, Byun et al. (2020) find that the dual targeting of glutamine metabolism and the PD-L1 checkpoint inhibitor augments anti-tumor immunity. Mechanistically, decreased glutamine availability attenuated S-glutathionylation of SERCA, resulting in an increase in cytosolic calcium, enhanced NF-κB activity, and upregulation of programmed death-ligand 1. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|