β-Catenin Regulates Cardiac Energy Metabolism in Sedentary and Trained Mice
| Autor: | Lesya V. Tumanovska, Anna Myronova, Volodymyr V. Balatskyi, Adam Olichwier, Oksana Palchevska, Ana-Maria Gan, Lina Bortnichuk, Viktor O. Navrulin, Pawel Dobrzyn, L. L. Macewicz, O. O. Piven |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
MAPK/ERK pathway
Kinase glucose metabolism Wnt signaling pathway oxidative phosphorylation Paleontology AMPK Lipid metabolism training-induced heart hypertrophy Biology Article General Biochemistry Genetics and Molecular Biology Cell biology Space and Planetary Science Endurance training lipid metabolism β-oxidation lcsh:Q Signal transduction Protein kinase A lcsh:Science Ecology Evolution Behavior and Systematics Wnt/β-catenin signaling |
| Zdroj: | Life Volume 10 Issue 12 Life, Vol 10, Iss 357, p 357 (2020) |
| ISSN: | 2075-1729 |
| DOI: | 10.3390/life10120357 |
| Popis: | The role of canonical Wnt signaling in metabolic regulation and development of physiological cardiac hypertrophy remains largely unknown. To explore the function of &beta catenin in the regulation of cardiac metabolism and physiological cardiac hypertrophy development, we used mice heterozygous for cardiac-specific &beta catenin knockout that were subjected to a swimming training model. &beta Catenin haploinsufficient mice subjected to endurance training displayed a decreased &beta catenin transcriptional activity, attenuated cardiomyocytes hypertrophic growth, and enhanced activation of AMP-activated protein kinase (AMPK), phosphoinositide-3-kinase&ndash Akt (Pi3K&ndash Akt), and mitogen-activated protein kinase/extracellular signal-regulated kinases 1/2 (MAPK/Erk1/2) signaling pathways compared to trained wild type mice. We further observed an increased level of proteins involved in glucose aerobic metabolism and &beta oxidation along with perturbed activity of mitochondrial oxidative phosphorylation complexes (OXPHOS) in trained &beta catenin haploinsufficient mice. Taken together, Wnt/&beta catenin signaling appears to govern metabolic regulatory programs, sustaining metabolic plasticity in adult hearts during the adaptation to endurance training. |
| Databáze: | OpenAIRE |
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