Development of immunity against Plasmodium falciparum malaria: clinical and parasitologic immunity cannot be separated
| Autor: | Eskild Petersen, Birthe Høgh, K David, Hanson Ap, N.T. Marbiah |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male Adolescent Plasmodium falciparum Biology Plasmodium law.invention Body Temperature law Immunity Pregnancy medicine Immunology and Allergy Parasite hosting Animals Humans Malaria Falciparum Pregnancy Complications Infectious Child Age Factors Infant biology.organism_classification medicine.disease Infectious Diseases Transmission (mechanics) Cross-Sectional Studies Child Preschool Immunology Protozoa Female Malaria |
| Zdroj: | The Journal of infectious diseases. 164(5) |
| ISSN: | 0022-1899 |
| Popis: | A total of 1622 individuals of all ages living under conditions of continuous malarial transmission in Liberia were enrolled in a cross-sectional study of parasite rates, positive parasite densities, and body temperatures. The age-specific Plasmodium falciparum-positive parasite densities were greatest at ages 0.5-1.0 year, then slowly declined into adulthood. The age-specific mean body temperature at parasite isodensity showed a steady decline even in the oldest age group. The results do not support the hypothesis that adults have higher body temperatures at a given parasite density than do children with the same parasite density. The age-specific P. falciparum parasite density for specific isotemperatures showed that a subgroup of children in the age group 0.5-1.0 year had low temperatures (less than 36.5 degrees C) despite high parasite densities. This indicates that low body temperature should be investigated further as a possible indicator of serious malaria in young children. Parasitologic and clinical immunity develops concomitantly and cannot be separated. The findings do not support the hypothesis that a special "anti-disease" immunity exists independently of parasitologic immunity. |
| Databáze: | OpenAIRE |
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