Acquired factor VIII deficiency: two case reports and a review of literature
| Autor: | George Chengxi Bao, Lan Mo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Cancer Research
medicine.medical_specialty Case Report Parvovirus B19 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences 0302 clinical medicine Melena Internal medicine hemic and lymphatic diseases Acquired factor VIII deficiency medicine Vaginal bleeding Acquired Factor VIII Deficiency Glucocorticoids Myositis Hematology medicine.diagnostic_test business.industry Acquired hemophilia A medicine.disease Venous thrombosis Oncology 030220 oncology & carcinogenesis Immunology Rituximab Intravenous Immunoglobulin medicine.symptom business Immunosuppression medicine.drug Partial thromboplastin time |
| Zdroj: | Experimental Hematology & Oncology |
| ISSN: | 2162-3619 |
| Popis: | Background Acquired factor VIII (FVIII) deficiency, or acquired hemophilia A (AHA), is a rare autoimmune disorder involving antibody-mediated depletion of coagulation FVIII, leading to severe, life-threatening bleeding. The condition is often associated with other autoimmune disorders, and its treatment involves replacement of FVIII and various modes of immunosuppression. Recently, a few noteworthy therapeutic advances have been made. We present two cases of severe AHA in Chinese women. One of these women developed this disorder in the setting of possible parvovirus B19 infection, which has not yet been reported in association with AHA. Other notable features of her case included paradoxical venous thrombosis and possible association with Sjogren’s syndrome and myositis. The other woman failed to respond to usual first-line therapies despite exhibiting a less severe clinical course, illustrating the varied but potentially stubborn behavior of this disorder. Case 1 An 87-year-old woman presented with diffuse ecchymoses, melena, vaginal bleeding. Labs showed hemoglobin (Hgb) nadir of 5.7 mg/dL, elevated partial thromboplastin time (PTT), FVIII level |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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