Prevalence and characterization of occult hepatitis B infection among blood donors in central Saudi Arabia
| Autor: | Gamal E. Eid, Malak M. El-Hazmi, Abdulkarim Alhetheel, Areej I. Alshayea |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male HBsAg medicine.medical_specialty 030106 microbiology Saudi Arabia lcsh:Medicine Blood Donors medicine.disease_cause Gastroenterology Serology 03 medical and health sciences Young Adult 0302 clinical medicine Internal medicine Genotype medicine Humans Hepatitis B Antibodies Genotyping Hepatitis B virus biology business.industry lcsh:R General Medicine Hepatitis B Middle Aged medicine.disease Virology Cross-Sectional Studies biology.protein 030211 gastroenterology & hepatology Original Article Female Antibody business Viral load |
| Zdroj: | Saudi Medical Journal Saudi Medical Journal, Vol 37, Iss 10, Pp 1114-1119 (2016) |
| ISSN: | 1658-3175 0379-5284 |
| DOI: | 10.15537/smj.2016.10.14705 |
| Popis: | Objectives: To evaluate the prevalence of occult hepatitis B viral infections (OBIs) among blood donors considering the clinical and epidemiological importance of identifying OBIs. Methods: A cross-sectional study conducted at King Khalid University Hospital, Riyadh, Saudi Arabia between January 2011 and January 2012. Blood donors (n=8501) were screened for Hepatitis B virus surface antigen (HBsAg) and hepatitis B core antibodies (HBcAb). All HBsAg-negative and HBcAb-positive samples were tested further for hepatitis B surface antibodies (HBsAb), hepatitis B virus (HBV)-DNA, and HBV genotyping. Results: Of the 8501 serum samples tested, 56 (0.7%) were positive and 8445 (99.3%) were negative for HBsAg. Among the HBsAg-negative samples, 198 (2.3%) were positive for HBcAb and these patients were suspected to have OBIs. Among the HBcAb-positive samples, 119 (60.1%) were positive while 79 (39.9%) were negative for HBsAb. Analysis of HBV-DNA for the suspected OBIs showed that 17 out of 198 samples (8.6%) yielded positive results, and all of them were HBsAb-negative. The viral load was low (less than 20-186 IU/mL) in all OBIs. Hepatitis B virus genotyping showed that 15 out of 17 samples (88.2%) were genotype D, and the other 2 samples (11.8%) were genotype E. Conclusion: The prevalence of OBIs among blood donors in Riyadh was 0.2%. Therefore, it is recommended that HBV molecular testing should be incorporated with serological assays for screening of blood donors. Saudi Med J 2016; Vol. 37 (10): 1114-1119 doi: 10.15537/smj.2016.10.14708 How to cite this article: Alshayea AI, Eid GE, El-Hazmi MM, Alhetheel AF. Prevalence and characterization of occult hepatitis B infection among blood donors in central Saudi Arabia. Saudi Med J . 2016 Oct;37(10):1114-9. doi: 10.15537/smj.2016.10.14708. |
| Databáze: | OpenAIRE |
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