Reproductive toxicity of BioThrax®in rabbits

Autor: Elise M. Lewis, Sandra L. Morseth, Cynthia Franco, Louise Simon, A. Thomas Waytes
Rok vydání: 2009
Předmět:
Zdroj: Birth Defects Research Part B: Developmental and Reproductive Toxicology. 86:370-376
ISSN: 1542-9741
1542-9733
DOI: 10.1002/bdrb.20205
Popis: BACKGROUND: An increasing number of women are being vaccinated during child-bearing years, including vaccination with BioThrax® (Anthrax Vaccine Adsorbed, or AVA). As only a limited number of studies exist in humans that have examined the effects of AVA on reproductive health, this study was conducted in order to evaluate the impact AVA vaccination may have on pregnant female rabbits and their offspring. METHODS: Two hundred female rabbits were vaccinated with saline, adjuvant, or AVA twice prior to mating and on one of two occasions during gestation, in order to have exposure to the antigen during organogenesis. Blood samples were collected from does and fetuses/kits to assess the development and in utero transfer of antibodies to Bacillus anthracisprotective antigen (anti-PA IgG). Half of the does underwent Caesarean-sectioning on gestation day 29 and a gross necropsy was performed on both the does and their fetuses. The other half were allowed to naturally deliver and gross necropsy of the does and their kits was performed on lactation day 29. RESULTS: ELISA results showed that anti-PA IgG was generated by the does and passed to the fetuses/kits at detectable levels. CONCLUSIONS: AVA directly, or indirectly through the production of anti-PA IgG, did not appear to have an adverse effect on the pregnant females or their offspring, as measured by mating and fertility indices, natural delivery observations, clinical signs, gross lesions, in utero growth and survival, morphological development, or kit viability. Birth Defects Res (Part B) 86:370–376, 2009. © 2009 Wiley-Liss, Inc.
Databáze: OpenAIRE
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