Normal tissue complication probability (NTCP) models for modern radiation therapy
| Autor: | Serena Monti, Roberto Pacelli, Manuel Conson, Laura Cella, Giuseppe Palma |
|---|---|
| Přispěvatelé: | Palma, G., Monti, S., Conson, M., Pacelli, R., Cella, L. |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.medical_treatment Normal tissue NTCP Hadron therapy 03 medical and health sciences 0302 clinical medicine Neoplasms Voxel-based analysi Medicine Humans Radiation Injurie Radiation Injuries Reirradiation Image-based outcome SBRT Radiotherapy business.industry Hematology Models Theoretical Radiation-induced morbidity Radiation therapy 030104 developmental biology Oncology 030220 oncology & carcinogenesis Hypofractionation Neoplasm Radiology business Complication Human |
| Zdroj: | Seminars in oncology. 46(3) |
| ISSN: | 1532-8708 |
| Popis: | Mathematical models of normal tissue complication probability (NTCP) able to robustly predict radiation-induced morbidities (RIM) play an essential role in the identification of a personalized optimal plan, and represent the key to maximizing the benefits of technological advances in radiation therapy (RT). Most modern RT techniques pose, however, new challenges in estimating the risk of RIM. The aim of this report is to schematically review NTCP models in the framework of advanced radiation therapy techniques. Issues relevant to hypofractionated stereotactic body RT and ion beam therapy are critically reviewed. Reirradiation scenarios for new or recurrent malignances and NTCP are also illustrated. A new phenomenological approach to predict RIM is suggested. |
| Databáze: | OpenAIRE |
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