Distinguishing Eosinophilic Esophagitis in Pediatric Patients
| Autor: | Jeffrey B. Schwimmer, Seema S. Aceves, John F. Bastian, Ranjan Dohil, Robert O. Newbury |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Biopsy Gastroenterology Internal medicine Eosinophilia Esophagitis Humans Medicine Child Eosinophilic esophagitis Retrospective Studies medicine.diagnostic_test business.industry Esophageal disease Retrospective cohort study medicine.disease Dysphagia Endoscopy Child Preschool Esophageal Stenosis Female Esophagoscopy medicine.symptom Deglutition Disorders business |
| Zdroj: | Journal of Clinical Gastroenterology. 41:252-256 |
| ISSN: | 0192-0790 |
| Popis: | To determine the clinical, endoscopic, and histologic criteria that distinguish children with eosinophilic esophagitis (EE) from those with non-EE diagnoses.EE is a disease of escalating incidence. Distinguishing children with EE from those with non-EE diagnosis can be difficult before endoscopy.A retrospective case-control study was performed for children with any degree of esophageal eosinophilic inflammation who underwent esophageal biopsy at Children's Hospital San Diego from January 1998 to December 2002. A database containing children who met histologic criteria for EE and an equivalent number of children who had milder esophageal eosinophilia (non-EE patients) was created to compare the 2 groups.The number of EE cases increased from 15 in 1998 to 35 in 2002. EE patients were predominantly school-aged boys; 5 of 102 were suspected to have EE before biopsy. Although EE and non-EE patients complained of vomiting and abdominal pain at equivalent rates, EE patients were 3 times more likely to complain of dysphagia [odds ratio (OR)=3.11, 95% confidence interval (CI) 1.55-6.65] and twice as likely to have stricture formation (OR=2.43, 95% CI 0.72-11.75). On endoscopy, patients with EE were 19-times more likely than non-EE patients to have endoscopic abnormalities (OR=19, 95% CI 9.0-45.88). Histologically, EE patients were more likely to have basal zone hyperplasia and degranulated eosinophils (OR=45 and 157, respectively).We demonstrate that school-aged children, particularly boys, who complain of dysphagia should raise the index of suspicion for EE. We also suggest that EE-associated strictures are more common than peptic strictures in children. |
| Databáze: | OpenAIRE |
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