Effect of plasma [K+] on the DC potential and on ion distributions between CSF and blood
| Autor: | S. W. Bledsoe, A. H. Mines |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Pathology
medicine.medical_specialty Physiology Blood Pressure Ion Potassium Chloride Cerebrospinal fluid Dogs Physiology (medical) Internal medicine medicine Arterial pH Distribution (pharmacology) Animals Infusions Parenteral Cerebrospinal Fluid Chemistry Dc potential Plasma Cations Monovalent Hydrogen-Ion Concentration Blood Physiological Phenomena Electrophysiology Bicarbonates Endocrinology Serum potassium Potassium Potentiometry Charged species |
| Zdroj: | Journal of applied physiology. 39(6) |
| ISSN: | 0021-8987 |
| Popis: | Keeping the arterial pH at 7.4 and PaCO2 at 40 mmHg in eight anesthetized dogs, we acutely raised plasma potassium concentration from 3.4 to 8.2 meq/1, then allowed it to decay back to control levels. The cerebrospinal fluid (CSF)-blood electrical potential difference (pd) increased 13.2 mV per 10-fold increase in plasma [K+]. Again keeping arterial pH at 7.4 and PaCO2 at 40 mmHg, we elevated plasma [K+] in four dogs from 3.3 to 8.0 meq/1 and maintained this level for 6 h. We found 1) that the PD increased from a control value of +1.3 to +8.9mV, showing no tendency to decay over the 6 h; and 2) that the change in PD did not affect the distribution of Na+, K+, H+, Cl-, or HCO3- between blood and CSF over the 6 h. These results suggest that under these conditions the PD between CSF and blood may play no effective role in determining the distributions of these charged species by 6 h. These results are contrasted with recent findings which suggest that H+ and HCO3- are distributed according to passive forces between CSF and blood. |
| Databáze: | OpenAIRE |
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