Chronic thromboembolic pulmonary hypertension: Comparison of dual-energy computed tomography and single photon emission computed tomography in canines

Autor: Long Jiang Zhang, Stefanie Mangold, Yan E. Zhao, Andrew C. Stubenrauch, Hong Zhu, Guangming Lu, Li Qi, Gui Fen Yang, Zong Hong Han, Jiang Wu, Chang Sheng Zhou, Chun Xiang Tang, U. Joseph Schoepf
Rok vydání: 2016
Předmět:
medicine.medical_specialty
Systole
Hypertension
Pulmonary
medicine.medical_treatment
030204 cardiovascular system & hematology
Single-photon emission computed tomography
Sensitivity and Specificity
030218 nuclear medicine & medical imaging
Radiography
Dual-Energy Scanned Projection
03 medical and health sciences
Dogs
0302 clinical medicine
medicine.artery
medicine
Animals
Radiology
Nuclear Medicine and imaging
Embolization
Tomography
Emission-Computed
Single-Photon
Blood Volume
Lung
medicine.diagnostic_test
business.industry
Reproducibility of Results
Dual-Energy Computed Tomography
General Medicine
medicine.disease
Pulmonary hypertension
Pulmonary embolism
Disease Models
Animal
medicine.anatomical_structure
Blood pressure
Chronic Disease
Pulmonary artery
Radiology
Pulmonary Embolism
business
Zdroj: European Journal of Radiology. 85:498-506
ISSN: 0720-048X
DOI: 10.1016/j.ejrad.2015.11.035
Popis: Purpose To compare diagnostic accuracy between dual-energy CT lung perfused blood volume (Lung PBV) imaging and single photon emission computed tomography (SPECT) in detecting chronic thromboembolic pulmonary hypertension (CTEPH) with histopathological results as reference standard in a canine model. Materials and methods Eighteen CTEPH canines were included into this experimental study. All procedures including paracentesis, embolization, scanning, pressure measurement and feeding medicine were repeated each two weeks, until systolic/diastolic pressure in canines was ≥30/15 mmHg or mean pulmonary artery pressure ≥20 mmHg, and then sacrificed for histopathology examination. Two radiologists (readers 1 and 2) and two nuclear radiologists (readers 3 and 4) analyzed images of conventional CT pulmonary angiography in dual-energy CT mode, Lung PBV imaging and SPECT, respectively. The presence, numbers, and locations of pulmonary emboli (PE) were recorded on a per-lobe basis. Pathological examination was served as reference standard. Sensitivity, specificity and accuracy of Lung PBV and SPECT were calculated. Kappa statistics were used to quantify inter-reader agreement. Results With histopathological results as reference standard, the sensitivities of 72.2%, 78.8%, 81.2%, specificities of 75.9%, 87.5%, 84.8%, accuracies of 73.8%, 83.1%, 83.1%, for readers 1, 2 and both with Lung PBV, respectively. Readers 3, 4 and both had sensitivities of 14.3%, 25.7%, 33.3%, specificities of 90.0%, 86.7%, 93.3%, accuracies of 49.2%, 53.8%, 60.0% with SPECT for detecting CTEPH. Inter-reader agreements were good for dual-energy CT (kappa = 0.662) and SPECT ( k = 0.706) for detecting CTEPH. Conclusion Dual-energy CT had a higher accuracy to detect CTEPH than SPECT in this canine model study.
Databáze: OpenAIRE
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