SARS‐CoV ‐2 spike trimer vaccine expressed in Nicotiana benthamiana adjuvanted with Alum elicits protective immune responses in mice

Autor:	Shi‐Jian Song, Heeyeon Kim, Eun Young Jang, Hyungmin Jeon, Hai‐Ping Diao, Md Rezaul Islam Khan, Mi‐Seon Lee, Young Jae Lee, Jeong‐hyun Nam, Seong‐Ryeol Kim, Young‐Jin Kim, Eun‐Ju Sohn, Inhwan Hwang, Jang‐Hoon Choi
Rok vydání:	2022
Předmět:	Mammals Mice Inbred BALB C COVID-19 Vaccines SARS-CoV-2 Immunity COVID-19 Plant Science Antibodies Neutralizing Mice Adjuvants Immunologic Tobacco Animals Humans Agronomy and Crop Science Biotechnology
Zdroj:	Plant Biotechnology Journal. 20:2298-2312
ISSN:	1467-7652 1467-7644
DOI:	10.1111/pbi.13908
Popis:	The ongoing coronavirus disease 2019 (COVID-19) pandemic has spurred rapid development of vaccines as part of the public health response. However, the general strategy used to construct recombinant trimeric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) proteins in mammalian cells is not completely adaptive to molecular farming. Therefore, we generated several constructs of recombinant S proteins for high expression in Nicotiana benthamiana. Intramuscular injection of N. benthamiana-expressed S
Databáze:	OpenAIRE
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