Simplified monomeric VHH-Fc antibodies provide new opportunities for passive immunization
| Autor: | Vikram Virdi, Henri De Greve, Shruti Bakshi, Anna Depicker |
|---|---|
| Přispěvatelé: | Structural Biology Brussels, Department of Bio-engineering Sciences |
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
medicine.drug_class Biomedical Engineering Bioengineering Monoclonal antibody Communicable Diseases 01 natural sciences 03 medical and health sciences 010608 biotechnology medicine Humans 030304 developmental biology 0303 health sciences biology Chemistry Immunoglobulin Fc Fragments Immunization Passive Biology and Life Sciences Antibodies Monoclonal Virology Fc domain Immunization Monoclonal biology.protein Antibody Biotechnology |
| Zdroj: | CURRENT OPINION IN BIOTECHNOLOGY |
| ISSN: | 0958-1669 1879-0429 |
| DOI: | 10.1016/j.copbio.2019.11.006 |
| Popis: | Simplified monomeric monoclonal antibodies consisting of a single-domain VHH, derived from camelid heavy-chain only antibodies, fused with the Fc domain of either IgG (VHH-IgG) or IgA (VHH-IgA) antibodies, are promising therapeutic proteins. These simplified single-gene encoded antibodies are much easier to manufacture and can be produced in plants and in yeast for bulk applications. These merits enable novel passive immunization applications, such as in-feed oral delivery of VHH-IgAs, which have successfully provided protection against a gastrointestinal infection in the piglet model. |
| Databáze: | OpenAIRE |
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