A review on multivesicular liposomes for pharmaceutical applications: preparation, characterization, and translational challenges
Autor: | Amruta Gorajiya, Kanan Panchal, Ajeet Kumar Singh, Sumeet Katke, Akash Chaurasiya |
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Rok vydání: | 2021 |
Předmět: |
Drug
Liposome Computer science Multivesicular liposomes media_common.quotation_subject Pharmaceutical Science Nanotechnology Frequent use Characterization (materials science) Drug Liberation Drug Delivery Systems Delayed-Action Preparations Liposomes Drug delivery Drug product Delivery system Particle Size media_common |
Zdroj: | Drug Delivery and Translational Research. 12:1569-1587 |
ISSN: | 2190-3948 2190-393X |
Popis: | Multivesicular liposomes (MVLs) are non-concentric, lipid-based micron-sized spherical particles. The usage of MVL for sustained drug delivery has seen progression over the last decade due to successful clinical and commercial applications. It provides attractive characteristics, such as high encapsulation efficiency, variety of sizes, structural stability, and different choices for the route of administration. Drug molecules are encapsulated in internal aqueous compartments of MVL, separated by lipid bilayer septa to form polyhedral structures. The integrity of these entrapped small molecules, peptides, or proteins is maintained throughout the therapy, thus providing sustained drug release on non-vascular administration. Despite the frequent use of unilamellar liposomes, characterization of MVLs is critical due to different puzzling problems, such as real-time size evaluation, initial burst, and in vivo performance. Moreover, available regulatory guidelines on liposomal drug product development are insufficient to assure ample in vitro-in vivo behavior of MVL. This review hereby highlights the innovations pertaining to development and manufacturing procedures, drug release mechanisms, and characterization techniques. The review also summarizes the applications, challenges, and future perspectives for successfully translating the research concept to a clinically accepted delivery system. Despite the intricacies involved in the development of MVL, establishing steadfast characterization techniques and regulatory paths could pave the way to its extensive clinical use. |
Databáze: | OpenAIRE |
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