Long-Term Effects of Exposure to Disease-Modifying Drugs in the Offspring of Mothers with Multiple Sclerosis: A Retrospective Chart Review
| Autor: | Alessandro Finkelzstejn, Tarso Adoni, Maria Fernanda Mendes, Sidney Gomes, Sonia Beatriz Felix Ribeiro, Marcus Goncalves, Rinaldo Claudino, Margarete de Jesus Carvalho, Elizabeth Regina Comini-Frota, Amilton Antunes Barreira, Soniza Vieira Alves-Leon, Elza Dias Tosta, Nerio Dutra Azambuja, Yara Dadalti Fragoso, Maria Cristina Brandao Giacomo, Renan Barros Domingues, Joseph Bruno Bidin Brooks, Mônica Koncke Fiuza Parolin, Fabio Siquineli, Nívea de Macedo Oliveira Morales, Rogerio Rizo Morales, Paulo Diniz da Gama, Heloisa Helena Ruocco, Damacio Ramón Kaimen-Maciel, Regina Maria Papais-Alvarenga, Andre Muniz, Denise S. D. Carneiro, Anderson Kuntz Grzesiuk |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
medicine.medical_specialty Pediatrics Multiple Sclerosis Adolescent Databases Factual Offspring Young Adult Pharmacotherapy Pregnancy medicine Humans Immunologic Factors Pharmacology (medical) FÁRMACOS Glatiramer acetate Young adult Child Psychiatry Adverse effect Retrospective Studies business.industry Infant Retrospective cohort study Glatiramer Acetate Interferon-beta medicine.disease Pregnancy Complications Psychiatry and Mental health Child Preschool Prenatal Exposure Delayed Effects Gestation Female Neurology (clinical) Peptides business Brazil medicine.drug |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1179-1934 1172-7047 |
| Popis: | Multiple sclerosis (MS) mainly affects women of fertile age. To date, the only recommendation for women with MS intending to become pregnant is to stop all treatment. This recommendation reflects the concerns about the effects of disease-modifying drugs (DMDs) on the offspring. The objective of the present study was to assess the potential long-term effects of maternal exposure to DMDs on the offspring. This was a retrospective study revising medical data on the offspring of women with MS. These women now have children aged at least 1 year and include a group of patients that were not exposed to any DMDs for at least 3 months prior to pregnancy and during the whole gestation (control group). Another group of patients had at least 2 weeks of exposure to DMDs, mainly to interferon beta or glatiramer acetate The women with MS participating in this study have children currently aged, on average, 6.6 years (range 1–39 years). There was no pattern of drug-related adverse events or complications in the children whose mothers were exposed to DMDs. No specific long-term adverse events were observed in the offspring of women with MS who were exposed to drugs during pregnancy. The profile of relevant diagnoses in their children was similar to that of children whose mothers had not been exposed to DMDs. The present retrospective study did not show a specific profile of long-term deleterious drug effects on children born from mothers who were exposed to drugs for MS treatment. |
| Databáze: | OpenAIRE |
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