The influence of Actinobacillus pleuropneumoniae infection on tulathromycin pharmacokinetics and lung tissue disposition in pigs
| Autor: | Tomasz Bladek, A. Gajda, Andrzej Posyniak, Artur Jabłoński |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Lung Diseases Veterinary medicine 040301 veterinary sciences Swine 030106 microbiology Cmax Pharmacology Disaccharides 0403 veterinary science 03 medical and health sciences Actinobacillus Infections Pharmacokinetics Heterocyclic Compounds medicine Animals Tulathromycin Tissue Distribution Actinobacillus pleuropneumoniae Lung Swine Diseases General Veterinary biology business.industry Pulmonary inflammation 04 agricultural and veterinary sciences biology.organism_classification medicine.anatomical_structure Plasma concentration Lung tissue business |
| Zdroj: | Journal of veterinary pharmacology and therapeutics. 39(2) |
| ISSN: | 1365-2885 |
| Popis: | A tulathromycin concentration and pharmacokinetic parameters in plasma and lung tissue from healthy pigs and Actinobacillus pleuropneumoniae (App)-infected pigs were compared. Tulathromycin was administered intramuscularly (i.m.) to all pigs at a single dose of 2.5 mg/kg. Blood and lung tissue samples were collected during 33 days postdrug application. Tulathromycin concentration in plasma and lung was determined by high-performance liquid chromatography with tandem mass spectrometry (LC-MS/MS) method. The mean maximum plasma concentration (Cmax ) in healthy pigs was 586 ± 71 ng/mL, reached by 0.5 h, while the mean value for Cmax of tulathromycin in infected pigs was 386 ± 97 ng/mL after 0.5 h. The mean maximum tulathromycin concentration in lung of healthy group was calculated as 3412 ± 748 ng/g, detected at 12 h, while in pigs with App, the highest concentration in lung was 3337 ± 937 ng/g, determined at 48 h postdosing. The higher plasma and lung concentrations in pigs with no pulmonary inflammation were observed at the first time points sampling after tulathromycin administration, but slower elimination with elimination half-life t1/2el = 126 h in plasma and t1/2el = 165 h in lung, as well as longer drug persistent in infected pigs, was found. |
| Databáze: | OpenAIRE |
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