Effects of a high sucrose diet and intragastric sucrose feeding on the dentinogenesis, dental caries, and mineral excretion of the young rat
| Autor: | Markku Larmas, Matti Puukka, Eeva-Liisa Hietala, Esa Pekkala |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Molar Sucrose medicine.medical_specialty Dentistry Dental Caries Statistics Nonparametric Rats Sprague-Dawley Excretion Random Allocation chemistry.chemical_compound stomatognathic system Dietary Sucrose Internal medicine medicine Dentin Animals Insulin Weaning General Dentistry Analysis of Variance Extracellular Matrix Proteins Odontoblasts Chemistry business.industry Sodium Phosphorus Radioimmunoassay General Medicine Dentinogenesis Rats Endocrinology medicine.anatomical_structure Potassium Calcium Female business |
| Zdroj: | Acta Odontologica Scandinavica. 58:155-159 |
| ISSN: | 1502-3850 0001-6357 |
| DOI: | 10.1080/000163500429145 |
| Popis: | Previous studies show that a high sucrose diet reduces the rate of primary dentinogenesis and increases dental caries, although their cause-effect relationship is still obscure. The purpose of this study was to explore whether the effect of sucrose load on the dentinogenesis and dental caries of young rat molars is mediated by systemic (intragastric) or by systemic and local (dietary) factors. At weaning (19 days), animals were randomized into the control, intragastric sucrose, and dietary sucrose groups for 4 weeks. The areas of dentin appositions and dentinal caries lesions were measured planimetrically. Caries was also determined with Shiffs staining and the width of predentin by histology. Urinary Ca, K, and Na levels were measured by flame photometry, urinary P levels using an UV method, and serum insulin levels using radioimmunoassay. Systemic and local sucrose load reduced dentin appositions and intragastric sucrose increased urinary Ca excretion. No differences in the width of predentin were noticed. Only dietary sucrose enhanced the occurrence and progression of caries. The present findings show that sucrose load reduces dentinogenesis by impairing the synthesis of dentin matrix, but also point out the crucial importance of the local sucrose challenge in the initiation of dental caries. |
| Databáze: | OpenAIRE |
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