Atazanavir plus ritonavir or saquinavir, and lopinavir/ritonavir in patients experiencing multiple virological failures
| Autor: | Margaret Johnson, Serap Sankoh, R B Wilber, Edwin DeJesus, Jeffrey Coco, Adriano Lazzarin, Claudia Rodriguez, Kenneth A. Lichtenstein, Anna Rightmire, Beatriz Grinsztejn |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
medicine.medical_specialty Anti-HIV Agents Pyridines Immunology Atazanavir Sulfate Organophosphonates Lopinavir/ritonavir HIV Infections Pyrimidinones Pharmacology Gastroenterology Drug Administration Schedule Lopinavir Drug Resistance Multiple Viral Internal medicine Antiretroviral Therapy Highly Active Medicine Immunology and Allergy Humans Tenofovir Saquinavir Ritonavir Reverse-transcriptase inhibitor business.industry Adenine HIV Protease Inhibitors Viral Load Lipids Atazanavir CD4 Lymphocyte Count Infectious Diseases Cholesterol HIV-1 RNA Viral Reverse Transcriptase Inhibitors Drug Therapy Combination business human activities Viral load Oligopeptides medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0269-9370 |
| Popis: | OBJECTIVE: To evaluate atazanavir/ritonavir (ATV/RTV) (300/100 mg) once daily, atazanavir/saquinavir (ATV/SQV) (400/1200 mg) once daily, and lopinavir/ritonavir (LPV/RTV) (400/100 mg) twice daily, each with tenofovir (300 mg) once daily and a nucleoside reverse transcriptase inhibitor in treatment-experienced HIV-infected patients. METHODS: Randomized, open-label, 48-week multicenter trial of 358 randomized adult patients who had failed two or more prior HAART regimens with baseline HIV RNA > or = 1000 copies/ml and CD4 cell count > or = 50 x 10(6) cells/l. RESULTS: The primary efficacy endpoint [plasma HIV RNA reduction assessed by time-averaged difference (TAD)] was similar for ATV/RTV and LPV/RTV [TAD 0.13; 97.5% confidence interval, -0.12 to 0.39] at 48 weeks. Mean reductions from baseline for ATV/RTV and LPV/RTV were comparable at 1.93 and 1.87 log10 copies/ml, respectively. Mean CD4 cell count increases were 110 and 121 x 10(6) cells/l for ATV/RTV, and LPV/RTV, respectively. The efficacy of ATV/SQV was lower than LPV/RTV by both these parameters. Declines in total cholesterol and fasting triglycerides were greater with ATV/RTV and ATV/SQV than with LPV/RTV (P < or = 0.005). Lipids in the LPV/RTV arm at week 48 generally increased from baseline. Lipid-lowering agents were used more frequently in the LPV/RTV arm than in the ATV arms (P < 0.05 versus ATV/RTV), as were antidiarrheal agents (P < or = 0.04 versus both ATV treatments). No new or unique safety findings emerged. CONCLUSIONS: ATV boosted with RTV is as effective and well tolerated as LPV/RTV in treatment-experienced patients, with a more favorable impact on serum lipids. Pharmacokinetically enhanced ATV provides a suitable choice for therapy of treatment-experienced HIV-infected patients. |
| Databáze: | OpenAIRE |
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