Agreement between units of measure for paediatric antibiotic utilisation surveillance using hospital pharmacy supply data
| Autor: | Beata Bajorek, Mona Mostaghim, Tom Snelling |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Antibiotics
Pharmaceutical Science lcsh:RS1-441 Pharmacy 030226 pharmacology & pharmacy Antimicrobial Stewardship 0302 clinical medicine Antimicrobial stewardship Pharmacology & Pharmacy Hospital pharmacy mesh:Retrospective Studies Original Research Pediatric Reference Standards Hospitals 3. Good health Anti-Bacterial Agents mesh:Australia mesh:Drug Utilization mesh:Antimicrobial Stewardship Drug Utilization medicine.medical_specialty Dose medicine.drug_class mesh:Reference Standards Pharmacy Service Vial lcsh:Pharmacy and materia medica 03 medical and health sciences Hospital medicine Quality of Health Care Retrospective Studies Hospitals Pediatric mesh:Hospitals business.industry lcsh:RM1-950 Australia Retrospective cohort study mesh:Hospital mesh:Anti-Bacterial Agents Defined daily dose lcsh:Therapeutics. Pharmacology mesh:Pediatric Emergency medicine mesh:Quality of Health Care business mesh:Pharmacy Service Pharmacy Service Hospital |
| Zdroj: | Pharmacy Practice (Granada) v.17 n.3 2019 SciELO España. Revistas Científicas Españolas de Ciencias de la Salud instname Pharmacy Practice Pharmacy Practice, Vol 17, Iss 3, p 1482 (2019) Pharmacy Practice (Granada), Volume: 17, Issue: 3, Article number: 1482, Published: 18 NOV 2019 |
| Popis: | © 2019, Grupo de Investigacion en Atencion Farmaceutica. All rights reserved. Background: Drug utilisation studies from paediatric hospitals that do not have access to patient level data on medication use are limited by a lack of standardised units of measures that reflect the varying daily dosage requirements among patients. The World Health Organization’s defined daily dose is frequently used in adult hospitals for benchmarking and longitudinal analysis but is not endorsed for use in paediatric populations. Objective: Explore agreement between standard adult-based defined daily doses (DDD) and paediatric estimates of daily injectable antibiotic use in a Paediatric Intensive Care Unit that does not have access to individual patient-level data. Methods: Hospital pharmacy antibiotic use reports and age-specific occupied bed-day data from 1 January 2010 to 31 May 2016 were extracted. Paediatric reference dosages and frequencies for antibiotics were defined and applied to three paediatric units of measure. Measures were applied to extracted data, agreement between antibiotic use measured in the adult DDD and each of the paediatric measures was assessed visually via Bland-Altman plots and linear regression for each antibiotic. Results: Thirty one different antibiotics were used throughout the study period. Despite varying daily dosages in grams, the daily use of vials was unchanged from birth to 18 years for thirteen antibiotics. Agreement between DDD and vial-based measures was closer than the total recommended daily dose that did not account for wastage during preparation and administration. Vial-based measures were unaffected by vial size changes due to drug shortage. Conclusions: Agreement between the DDD and vial-based measures of use supports the use of DDD for select antibiotics that may be targeted by antimicrobial stewardship programs. Vial based measures should be further explored in hospitals with single vial policies; detailed understanding of hospital practice is needed before inter-hospital comparisons are made. |
| Databáze: | OpenAIRE |
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