Efficacy of a spot-on combination of fluralaner plus moxidectin (Bravecto® Plus) in cats following repeated experimental challenge with a field isolate of Ctenocephalides felis

Autor:	Frank Guerino, Petr Fisara, Fangshi Sun
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	0301 basic medicine Fluralaner Veterinary medicine Flea Randomization Efficacy animal diseases 030231 tropical medicine Biology lcsh:Infectious and parasitic diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine parasitic diseases lcsh:RC109-216 Ctenocephalides Fipronil CATS Acaricide Cat biology.organism_classification bacterial infections and mycoses Ctenocephalides felis Moxidectin 030104 developmental biology Infectious Diseases chemistry Fleas Parasitology Bravecto
Zdroj:	Parasites & Vectors, Vol 12, Iss 1, Pp 1-7 (2019)
ISSN:	1756-3305
DOI:	10.1186/s13071-019-3512-x
Popis:	Background A spot-on formulation of fluralaner plus moxidectin has been designed to provide long-term protection against fleas and ticks, prevent heartworm disease and treat gastrointestinal nematode infections in cats. The objective of this study was to determine the efficacy of this product against fleas collected from a household with repeated fipronil failures following owner-administered treatments. Methods Thirty cats were randomized to three equal groups: (A) untreated controls; (B) to receive a single application of fluralaner plus moxidectin (Bravecto® Plus) at 40 mg/kg and 2 mg/kg body weight, respectively; and (C) three applications at one month intervals with a spot-on formulation of fipronil and (S)-methoprene (Frontline® Plus) at 0.5 ml manufacturer recommended dose. Flea challenges were completed on Days −6 (for randomization), −1, 7, 14, 28, 42, 56, 70, 77, 84 and 91. Flea counts were completed 48 hours after initial treatment and 48 hours following each subsequent challenge. Results Fleas were found on all control and all fipronil and (S)-methoprene treated cats at every assessment. From Day 2 to Day 93, all cats in the fluralaner plus moxidectin group were flea-free, with one exception (Day 58; three fleas counted on one cat); control group flea counts ranged between 34–109, and fipronil and (S)-methoprene group counts ranged between 1–79. At each assessment after Day 0, compared to the control group, geometric mean flea counts were significantly lower in the fipronil and (S)-methoprene group (P ≤ 0.04) and in the fluralaner plus moxidectin group (P
Databáze:	OpenAIRE
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