Five-Year Follow-Up of Concomitant Accelerated Hypofractionated Radiation in Advanced Squamous Cell Carcinoma of the Buccal Mucosa: A Retrospective Cohort Study
| Autor: | Adeel Illyas, Sarah Jamshed, Arif Jamshed, Abu Bakar Hafeez Bhatti, Hassan Iqbal, Riaz Hussain, Natasha Hameed, Muhammad Irfan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Article Subject lcsh:Medicine Deoxycytidine Disease-Free Survival General Biochemistry Genetics and Molecular Biology Internal medicine medicine Carcinoma Humans Survival rate Aged Retrospective Studies Mouth neoplasm General Immunology and Microbiology business.industry lcsh:R Mouth Mucosa Induction chemotherapy Radiotherapy Dosage General Medicine Middle Aged medicine.disease Gemcitabine Survival Rate Regimen Concomitant Buccal Mucosa Squamous Cell Carcinoma Clinical Study Carcinoma Squamous Cell Female Mouth Neoplasms Cisplatin business medicine.drug |
| Zdroj: | BioMed Research International, Vol 2015 (2015) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | In resource limited settings, induction chemotherapy with Gemcitabine and Cisplatinum and concurrent hypofractionated chemoradiation for locally advanced carcinoma of buccal mucosa (BMSCC) are a cost effective option but remain under reported. The objective of this study was to report long term survival outcome after concurrent hypofractionated radiotherapy in locally advanced BMSCC. Between February 2005 and 2009, 63 patients received treatment. Induction chemotherapy (IC) regimen consisted of two drugs: Gemcitabine and Cisplatin. All patients received 55 Gy of radiation in 20 fractions with concurrent single agent Cisplatin (75 mg/m2). Five-year overall survival (OS), disease-free survival (DFS), and progression-free survival (PFS) were determined. Based on AJCC staging, 7 (11%) patients were stage III, 31 (49%) stage IV a, and 25 (40%) stage IVb at presentation. After IC, 8 (18%) patients had complete radiological response, 33 (73%) had partial response, and 4 (9%) had stable disease. After concurrent hypofractionated chemoradiation, thirty-nine (62%) patients were complete responders and 24 (38%) had stable disease. With a minimum follow-up of 60 months, 5-year OS, DFS, and PFS were 30%, 49%, and 30%, respectively. In locally advanced buccal mucosa squamous cell carcinoma, concurrent hypofractionated chemoradiation results in acceptable survival and regimen related toxicity. |
| Databáze: | OpenAIRE |
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