Comparison of remifentanil with dexmedetomidine for monitored anaesthesia care in elderly patients during vertebroplasty and kyphoplasty
| Autor: | Woon Suk Hwang, Eun Young Park, Soo Kyung Lee, Sung Wook Jang, Jung Min Lee, Sang Jun Lee |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Mean arterial pressure medicine.medical_specialty Sedation Conscious Sedation Remifentanil Blood Pressure Biochemistry Loading dose 03 medical and health sciences 0302 clinical medicine kyphoplasty monitored anaesthesia care elderly Double-Blind Method Piperidines Heart Rate 030202 anesthesiology Heart rate medicine Humans Prospective Studies Dexmedetomidine Prospective cohort study Aged Aged 80 and over business.industry Biochemistry (medical) dexmedetomidine Research Reports Cell Biology General Medicine Analgesics Non-Narcotic Middle Aged vertebroplasy Surgery Blood pressure Anesthesia Female medicine.symptom business Anesthetics Intravenous 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | The Journal of International Medical Research |
| ISSN: | 1473-2300 0300-0605 |
| Popis: | ObjectivesThis clinical trial is registered at ClinicalTrials.gov. (NCT02476981) This randomized, prospective double-blind study compared remifentanil with dexmedetomidine for monitored anaesthesia care during minimally invasive corrections of vertebral compression fractures (vertebroplasty or kyphoplasty).MethodsPatients > 65 years of age with American Society of Anesthesiologists (ASA) classification I–III, scheduled for vertebroplasty or kyphoplasty under monitored anaesthesia care, received remifentanil (i.v. infusion 1–5 µg/kg/h) or dexmedetomidine (loading dose 0.3–0.4 µg/kg followed by i.v. infusion 0.2–1 µg/kg/h) to maintain observer's assessment of alertness/sedation (OAA/S) scale ResultsThere were no statistically significant differences in demographic data between the remifentanil ( n = 37) and dexmedetomidine groups ( n = 38). Patients on dexmedetomidine experienced lower mean arterial pressure (MAP) and heart rate (HR), and higher SpO2values, than patients on remifentanil. Compared with dexmedetomidine, remifentanil produced more respiratory depression, oxygen desaturation, and reduced the need for additional intraoperative opioids. There were no significant between-group differences in terms of recovery time, investigators’ satisfaction scores, or patients’ overall pain experiences.ConclusionsDuring monitored anaesthesia care, dexmedetomidine provides less respiratory depression, lower MAP and HR, but also less analgesic effect than remifentanil in elderly patients undergoing vertebroplasty or kyphoplasty. |
| Databáze: | OpenAIRE |
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