A dual-responsive doxorubicin–indoximod conjugate for programmed chemoimmunotherapy

Autor:	Zhaoxuan Yang, Jiaqi Huang, Yaying Lin, Xiangjie Luo, Haojin Lin, Hongyu Lin, Jinhao Gao
Rok vydání:	2022
Předmět:	Chemistry (miscellaneous) Biochemistry Genetics and Molecular Biology (miscellaneous) Molecular Biology Biochemistry
Zdroj:	RSC Chemical Biology. 3:853-858
ISSN:	2633-0679
DOI:	10.1039/d1cb00257k
Popis:	Herein we report a dual-responsive doxorubicin-indoximod conjugate (DOXIND) for programmed chemoimmunotherapy. This conjugate is able to release doxorubicin and indoximod upon exposure to appropriate stimuli for synergistic chemotherapy and immunotherapy, respectively. We demonstrate its promoting effects on immune response and inhibiting effects on tumor growth through a series of
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86dc888bba970a0ac96017408c6024ec https://doi.org/10.1039/d1cb00257k Zobrazit plný text záznamu