Allergy and acute leukaemia in children with Down syndrome: a population study. Report from the Mexican inter-institutional group for the identification of the causes of childhood leukaemia
| Autor: | Raquel Amador-Sánchez, Juan Carlos Núñez-Enríquez, M del Carmen Rodriguez-Zepeda, Francisco Javier Álvarez-Rodríguez, Victoria Bolea-Murga, Armando Martínez-Avalos, Roberto Rivera-Luna, Luz Victoria Flores-Villegas, Roberto Bernáldez-Ríos, Nora Nancy Núñez-Villegas, Aurora Medina-Sanson, Nancy Carolina Reyes-Zepeda, Elisa Dorantes-Acosta, Rogelio io Paredes-Aguilera, Martha Margarita Velázquez-Aviña, José Gabriel Peñaloza-González, Rocío Cárdenas-Cardós, Arturo Fajardo-Gutiérrez, José Arellano-Galindo, José Refugio Torres-Nava, Angélica Rangel-López, Vilma Carolina Bekker-Méndez, J. de Diego Flores-Chapa, Juan Manuel Mejía-Aranguré, Elva Jiménez-Hernández, E P Buchán-Durán, Janet Flores-Lujano, Fabio Abdiel Salamanca-Gómez, Clara Gorodezky |
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| Rok vydání: | 2013 |
| Předmět: |
Cancer Research
medicine.medical_specialty Pediatrics Down syndrome Allergy acute lymphoblastic leukaemia business.industry Short Communication Case-control study allergy medicine.disease Childhood leukaemia Precursor Cell Lymphoblastic Leukemia Lymphoma children Oncology El Niño hemic and lymphatic diseases Epidemiology Medicine Population study epidemiology business |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | Background: Allergies have been described as protective factors against the development of childhood acute leukaemia (AL). Our objective was to investigate the associations between allergy history and the development of AL and acute lymphoblastic leukaemia (ALL) in children with Down syndrome (DS). Methods: A case–control study was performed in Mexico City. The cases (n=97) were diagnosed at nine public hospitals, and the controls (n=222) were recruited at institutions for children with DS. Odds ratios (OR) were calculated. Results: Asthma was positively associated with AL development (OR=4.18; 95% confidence interval (CI): 1.47–11.87), whereas skin allergies were negatively associated (OR=0.42; 95% CI: 0.20–0.91). Conclusion: Our findings suggest that allergies and AL in children with DS share biological and immune mechanisms. To our knowledge, this is the first study reporting associations between allergies and AL in children with DS. |
| Databáze: | OpenAIRE |
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