Brain Atrophy Is Associated with Disability Progression in Patients with MS followed in a Clinical Routine
| Autor: | Ellen Carl, Jesper Hagemeier, Robert Zivadinov, Channa Kolb, Deepa P. Ramasamy, Bianca Weinstock-Guttman, David Hojnacki, N. Bergsland, Michael G. Dwyer, Ivo Paunkoski, Emanuele Ghione, Diego Silva, Dejan Jakimovski |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Multiple Sclerosis Neuroimaging Article 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Atrophy Lateral Ventricles medicine Humans Radiology Nuclear Medicine and imaging In patient skin and connective tissue diseases Retrospective Studies Clinically isolated syndrome business.industry Multiple sclerosis Retrospective cohort study Middle Aged medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Ventricle Brain size Disease Progression Female sense organs Neurology (clinical) Radiology business 030217 neurology & neurosurgery |
| Zdroj: | American Journal of Neuroradiology. 39:2237-2242 |
| ISSN: | 1936-959X 0195-6108 |
| Popis: | BACKGROUND: The assessment of brain atrophy in a clinical routine is not performed routinely in multiple sclerosis (MS). OBJECTIVES: To determine feasibility of brain atrophy measurement and its association with disability progression (DP), in MS patients followed in a clinical routine over 5 years. METHODS: 1,815 subjects, of which 1,514 MS and 137 with clinically isolated syndrome (CIS) patients, and 164 healthy individuals (HI) were collected retrospectively. Of 11,794 MRI brain scans included in the analysis, 8,423 MRIs were performed on a 3T and 3,371 MRIs on a 1.5T scanner. All patients received 3D T1-WI and T2-FLAIR exams at all time points of the study. Whole brain volume changes were measured by percentage brain volume change (PBVC) using SIENA and percentage normalized brain volume (NBV) change using SIENAX on 3D T1-WI, and percentage lateral ventricle volume (LVV) change using NeuroSTREAM on T2-FLAIR. Annualized rates were calculated. RESULTS: PBVC failed in 36.7% of the subjects, percentage NBV change in 19.2%, and percentage LVV change in 3.3%, because of protocol changes, poor scan quality, artifacts and anatomical variations. Annualized brain volume changes were significantly different between MS and HI for PBVC (p |
| Databáze: | OpenAIRE |
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