Laparoscopic hepatectomy for liver metastasis of lung large-cell neuroendocrine carcinoma: A case report

Autor: Kazuyoshi Kajimoto, Toshiko Sakuma, Masahiro Tominaga, Hironobu Goto, Toshihiko Yoshida, Yasuhiro Fujino, Dai Otsubo, Akinobu Furutani, Hisoka Yamane, Takashi Yamagishi, Sachiko Yoshida, Masayasu Nishi, Taku Matsumoto
Rok vydání: 2019
Předmět:
medicine.medical_specialty
Radiography
medicine.medical_treatment
ICG
indocyanine green
Article
WHO
World Health Organization
SUVmax
maximum standardized uptake value
Metastasis
Lesion
03 medical and health sciences
LCNEC
large-cell neuroendocrine carcinoma
0302 clinical medicine
Case report
NET
neuroendocrine tumor
medicine
Lung cancer
Liver metastasis
Pathological
Survival rate
FDG-PET
18F-fluorodeoxyglucose positron emission tomography
Lung
business.industry
Large cell neuroendocrine carcinoma
ProGRP
progastrin-releasing peptide
respiratory system
medicine.disease
SCLC
small cell lung carcinoma
respiratory tract diseases
CT
computed tomography
medicine.anatomical_structure
S7
segment 7
Laparoscopic hepatectomy
030220 oncology & carcinogenesis
030211 gastroenterology & hepatology
Surgery
Radiology
Hepatectomy
medicine.symptom
business
MRI
magnetic resonance imaging
Zdroj: International Journal of Surgery Case Reports
ISSN: 2210-2612
DOI: 10.1016/j.ijscr.2019.10.026
Popis: Highlights • Lung large-cell neuroendocrine carcinoma (LCNEC) is an aggressive and a rare type of lung cancer. • The prognosis of LCNEC with distant metastasis is extremely poor. • Surgical resection for liver metastasis of LCNEC may improve prognosis.
Introduction Lung large-cell neuroendocrine carcinoma (LCNEC) is an aggressive and a rare type of lung cancer, and the prognosis of LCNEC with distant metastasis is extremely poor, with a five-year survival rate of 0%. Here, we report a case of laparoscopic hepatectomy for liver metastasis of lung LCNEC. Presentation of case A 63-year-old man received a routine physical examination, and abnormal chest radiographic findings were observed; chest computed tomography (CT) in our hospital revealed that the patient had left pneumothorax and a lesion measuring 18 mm in the inferior lingular segment of the lung. The patient underwent thoracoscopic lobectomy, and the final pathological diagnosis was lung LCNEC. Four years after surgery, abdominal CT revealed a mass measuring 27 mm in the liver. The patient underwent laparoscopic partial hepatectomy, and postoperative pathological examination showed liver metastasis of LCNEC. There was no sign of recurrence 6 months after hepatectomy. Discussion LCNEC with distant metastasis has a poor response to systemic chemotherapy, and the median survival time of patients with distant metastasis is estimated to be approximately 6 months, with a five-year survival rate of 0%. Although the common site of metastasis from LCNEC is the liver, there are no previous reports of hepatectomy for liver metastasis of LCNEC. Conclusion We report a case of laparoscopic hepatectomy for liver metastasis of lung LCNEC. It is suggested that surgical resection for solitary distant metastasis of LCNEC may improve prognosis.
Databáze: OpenAIRE
Externí odkaz: