Time-dynamic pulse modulation of spinal cord stimulation reduces mechanical hypersensitivity and spontaneous pain in rats

Autor: Carl Y. Saab, Jason W. Leung, Muhammad M. Edhi, Kiernan Bloye, Amanda Baanante, Rosana Esteller, Ki-Soo Jeong, Kevin N. Vanent, Changfang Zhu, Lonne Heijmans
Přispěvatelé: Anesthesiologie, RS: MHeNs - R3 - Neuroscience
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Time Factors
MULTICENTER
Stimulation
CHRONIC BACK
Electroencephalography
Tonic (physiology)
Rats
Sprague-Dawley
Stereotaxic Techniques
0302 clinical medicine
Peripheral Nerve Injuries
Medicine
Pain Measurement
Spinal Cord Stimulation
Multidisciplinary
10-KHZ HIGH-FREQUENCY
medicine.diagnostic_test
NEUROPATHIC PAIN
Chronic pain
Sciatic Nerve
Electrodes
Implanted
Spinal Cord
Hyperalgesia
Somatosensory system
Neuropathic pain
Neuronal physiology
Sensory processing
Pain Threshold
Science
Neural circuits
Article
KILOHERTZ-FREQUENCY
THERMAL HYPERALGESIA
Amplitude modulation
03 medical and health sciences
Sensorimotor processing
Animals
Pain Management
INTENSITY
business.industry
medicine.disease
Crossover study
Rats
MODEL
030104 developmental biology
PATTERNS
Neuralgia
LEG PAIN
business
Neuroscience
030217 neurology & neurosurgery
Pulse-width modulation
Zdroj: Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports, 10(1):20358. Nature Publishing Group
Scientific Reports
ISSN: 2045-2322
Popis: Enhancing the efficacy of spinal cord stimulation (SCS) is needed to alleviate the burden of chronic pain and dependence on opioids. Present SCS therapies are characterized by the delivery of constant stimulation in the form of trains of tonic pulses (TPs). We tested the hypothesis that modulated SCS using novel time-dynamic pulses (TDPs) leads to improved analgesia and compared the effects of SCS using conventional TPs and a collection of TDPs in a rat model of neuropathic pain according to a longitudinal, double-blind, and crossover design. We tested the effects of the following SCS patterns on paw withdrawal threshold and resting state EEG theta power as a biomarker of spontaneous pain: Tonic (conventional), amplitude modulation, pulse width modulation, sinusoidal rate modulation, and stochastic rate modulation. Results demonstrated that under the parameter settings tested in this study, all tested patterns except pulse width modulation, significantly reversed mechanical hypersensitivity, with stochastic rate modulation achieving the highest efficacy, followed by the sinusoidal rate modulation. The anti-nociceptive effects of sinusoidal rate modulation on EEG outlasted SCS duration on the behavioral and EEG levels. These results suggest that TDP modulation may improve clinical outcomes by reducing pain intensity and possibly improving the sensory experience.
Databáze: OpenAIRE
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